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MOAP1 (modulator of apoptosis 1) is a 352 amino acid protein encoded by the human gene MOAP1. MOAP1 belongs to the PNMA family and contains one BH3-like domain and one RASSF1-binding domain. It is required for death receptor-dependent apoptosis. When MOAP1 is associated with RASSF1, it promotes a Bax conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation. MOAP1 is a homo-dimer and, under normal circumstances, is held in an inactive conformation by an intramolecular interaction. Binding to RASSF1 isoform A (RASSF1A) relieves this inhibitory interaction and allows further binding to Bax. MOAP1 will also bind to Bcl-2 and Bcl-x.
Informations pour la commande
Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps MOAP1 (MOAP-1-N) | sc-130558 | 200 µg/ml | $316.00 | |||
MOAP1 (MOAP-1-N): m-IgG Fc BP-HRP Kit | sc-539827 | 200 µg Ab; 10 µg BP | $354.00 | |||
MOAP1 (MOAP-1-N): m-IgG1 BP-HRP Kit | sc-541734 | 200 µg Ab; 20 µg BP | $354.00 |