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Inhibitor of apoptosis proteins (IAPs) contain conserved, unique N-terminal baculovirus IAP repeats (BIRs) and usually a C-terminal RING finger domain. Immunoprecipitation and Western blot analysis indicate that ML-IAP, also known as melanoma inhibitor of apoptosis protein, kidney inhibitor of apoptosis protein (KIAP), livin or BIRC7, binds to caspase-3, -7 and -9, but only inhibits caspase-9. Additionally, ML-IAP physically interacts with Smac through its BIR domain with a very high affinity and this interaction is very specific. The gene which encodes ML-IAP maps to human chromosome 20q13.3. There is controversy regarding the localization of this protein and its involvement in apoptosis, but it has been suggested that ML-IAP may play a complex role in the regulation of apoptosis.
Informations pour la commande
Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps ML-IAP (A-1) | sc-166390 | 200 µg/ml | $316.00 | |||
ML-IAP (A-1): m-IgG Fc BP-HRP Kit | sc-540094 | 200 µg Ab; 10 µg BP | $354.00 | |||
ML-IAP (A-1): m-IgG2a BP-HRP Kit | sc-546849 | 200 µg Ab; 10 µg BP | $354.00 |