Molecular structure of Methimazole, CAS Number: 60-56-0
Methimazole (CAS 60-56-0)
See product citations (4)
Alternate Names:
Favistan; Mercazolyl; Strumazol
Application:
Methimazole is a JAK/STAT signaling pathway inhibitor
CAS Number:
60-56-0
Purity:
≥98%
Molecular Weight:
114.17
Molecular Formula:
C4H6N2S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Methimazole is a thioamide compound that functions as an inhibitor of thyroid hormone synthesis. It acts by interfering with the incorporation of iodine into tyrosine residues in the thyroglobulin molecule, thereby inhibiting the formation of thyroid hormones. Methimazole mode of action involves the inhibition of the enzyme thyroperoxidase, which causes the iodination of tyrosine residues and the coupling of iodotyrosines to form thyroid hormones. By disrupting this process, methimazole effectively reduces the production of thyroid hormones in experimental models. Methimazole′s ability to target the thyroid gland and interfere with hormone synthesis for investigating the regulation of thyroid function and related physiological processes. Its precise mechanism of action at the molecular level.
Methimazole (CAS 60-56-0) References
- Methimazole as an antioxidant and immunomodulator in thyroid cells: mechanisms involving interferon-gamma signaling and H(2)O(2) scavenging. | Kim, H., et al. 2001. Mol Pharmacol. 60: 972-80. PMID: 11641425
- Methimazole protects lungs during hepatic ischemia-reperfusion injury in rats: an effect not induced by hypothyroidism. | Tütüncü, T., et al. 2007. J Gastroenterol Hepatol. 22: 704-9. PMID: 17444859
- Methimazole-induced hypothyroidism causes cellular damage in the spleen, heart, liver, lung and kidney. | Cano-Europa, E., et al. 2011. Acta Histochem. 113: 1-5. PMID: 19775732
- Mechanisms of methimazole cytotoxicity in isolated rat hepatocytes. | Heidari, R., et al. 2013. Drug Chem Toxicol. 36: 403-11. PMID: 23256569
- A method for the determination of total and reduced methimazole in various biological samples. | Chwatko, G., et al. 2014. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 31: 1009-16. PMID: 24645729
- Percutaneous absorption of methimazole: an in vitro study of the absorption pharmacokinetics for two different vehicles. | Hill, KE., et al. 2015. J Vet Pharmacol Ther. 38: 581-9. PMID: 25683868
- Cardiovascular Responses to 5-hydroxytryptamine in Methimazole-induced Hypothyroid Pithed Rats. | Cobos-Puc, L., et al. 2020. Arch Med Res. 51: 310-316. PMID: 32284200
- Desensitization to Methimazole. | Mazhari, A., et al. 2021. Endocr Pract. 27: 185-190. PMID: 33779553
- Antithyroid Drug Treatment in Graves' Disease. | Chung, JH. 2021. Endocrinol Metab (Seoul). 36: 491-499. PMID: 34130446
- Effect of Methimazole Therapy on Thyroid Pathohistology That May Mimic Thyroid Malignancy. | Punda, A., et al. 2020. Acta Clin Croat. 59: 146-148. PMID: 34219897
- Acute pancreatitis caused by methimazole/carbimazole assumption: a case-series. | Sarro, A., et al. 2023. Minerva Endocrinol (Torino). 48: 115-120. PMID: 34825556
- Methimazole and α-lipoic acid as metallo-β-lactamases inhibitors. | Zhang, B., et al. 2022. J Antibiot (Tokyo). 75: 282-286. PMID: 35197545
- Comparison of antithyroid effects and hepatic complications of methimazole with catechin and its nanoencapsulation form in adult male rats. | Mohamadizadeh, E., et al. 2022. J Complement Integr Med. 19: 591-598. PMID: 35918303
- Methimazole-induced gestational hypothyroidism affects the offspring development and differently impairs the conditioned fear in male and female adulthood rodents. | Hipólito, LTM., et al. 2023. Int J Dev Neurosci. 83: 108-120. PMID: 36445265
- Methimazole and sodium perchlorate exert anti-thyroidal effects in the T3-induced Xenopus laevis metamorphosis assay: A rapid assay for screening thyroid disrupting chemicals. | Zhou, W., et al. 2023. Aquat Toxicol. 257: 106431. PMID: 36827831
Inhibitor of:
μ-crystallin, ADO, AOX1, AOX3, AOX4, c-Erb-A α-1, c-Erb-A β-1, CSH1, CYB561D1, Cyp2c29, DEHAL1, DHRS4, DHRS7C, DIO1, DIO2, EG665927, FMO1, FMO2, FMO3, FMO4, FMO5, FMO6, FMO9, FOXE2, Fumarylacetoacetase, HGD, hornerin, Iodothyronine deiodinase (DIO), LPO, MG50, MoCo Sulfurase, MOCS3, MOXD2, NAT-16, Olfr1104, Olfr1426, Olfr804, Olfr826, OR2L5, OR2T3, OR4F15, OR51B2, OR51I1, OR5L1, OR5M8, OR8J3, OXNAD1, peroxidase, Pmel17, PRX2, PYROXD1, RDH16, Renalase, SELB, Selenoprotein I, Selenoprotein N, Selenoprotein O, Selenoprotein R, SEP15, SEPHS2, Spot 14, SULT1C3, TAAR6, thyroid peroxidase, Thyroperoxidase, Thyroxine, TRα, TRβ1, TRP2, TSHβ, TSHR, TYW1, Vmn2r2, Vmn2r65, Vmn2r90, VN1R4, and ZADH2.Activator of:
c-Erb-A α-1, KCNG1, KCNG2, MUP16, OR2M2, OR2T27, OR5AC2, OR5K4, OR7A17, PAM, Pax-8, Pcdhgb4, TBG, Thyroglobulin, Thyroxine, Triiodothyronine, and V1RL1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Methimazole, 10 g | sc-205747 | 10 g | $70.00 | |||
Methimazole, 25 g | sc-205747A | 25 g | $112.00 |