MCCA Antibody (D-11): sc-376647
- MCCA Antibody (D-11) is a mouse monoclonal IgG2a κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 465-503 within an internal region of MCCA of human origin
- recommended for detection of MCCA of mouse, rat and human origin by WB, IP, IF and ELISA
- m-IgG Fc BP-HRP and m-IgG2a BP-HRP are the preferred secondary detection reagents for MCCA Antibody (D-11) for WB applications. These reagents are now offered in bundles with MCCA Antibody (D-11) (see ordering information below).
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SEE ALSO...
MCCA Antibody (D-11) is a mouse monoclonal IgG2a antibody that detects methylcrotonoyl-CoA carboxylase α chain (MCCA) in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). MCCA plays a vital role in the metabolism of branched-chain amino acids, specifically in the catabolism of leucine, where MCCA catalyzes the carboxylation of 3-methylcrotonyl-CoA to produce 3-methylglutaconyl-CoA, a crucial step in energy production and metabolic regulation. MCCA is located in the mitochondrial matrix, which highlights the importance of mitochondrial function in cellular metabolism and energy homeostasis. The gene encoding the 725 amino acid MCCA protein is situated on chromosome 3q26-q28 and consists of 19 exons, with mutations leading to 3-methylcrotonylglycinuria, an autosomal recessive disorder that can result in severe metabolic disturbances. Anti-MCCA antibody (D-11) is an essential tool for researchers studying metabolic disorders and mitochondrial function, providing insights into the biochemical pathways that are critical for maintaining cellular health and energy balance.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MCCA Antibody (D-11) | sc-376647 | 200 µg/ml | $322.00 | |||
MCCA Antibody (D-11): m-IgG Fc BP-HRP Bundle | sc-540623 | 200 µg Ab; 10 µg BP | $361.00 | |||
MCCA Antibody (D-11): m-IgG2a BP-HRP Bundle | sc-546937 | 200 µg Ab; 10 µg BP | $361.00 | |||
MCCA (D-11) Neutralizing Peptide | sc-376647 P | 100 µg/0.5 ml | $69.00 |