Sm and Sm-like (LSm) proteins form donut-shaped heptameric complexes that are involved in various steps of RNA metabolism. LSm proteins are ubiquitously expressed and facilitate RNA-protein interactions and structural changes that are required during ribosomal subunit assembly. LSm8, also known as YJR022W, is a member of the snRNP Sm proteins family. It is a component of the LSm2-8 complex which plays a role in the processing of pre-snoRNAs, pre-tRNAs and pre-rRNAs, as well as the turnover of pre-mRNAs. The LSm2-8 complex is also essential for the nuclear localization of the U6 snRNA. LSm8 localizes to the nucleus and specifically binds the U6 snRNA 3′-terminal U-tract.
Informations pour la commande
Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps LSm8 (2527C6a) | sc-81315 | 100 µg/ml | $333.00 |