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Lissencephaly (smooth brain) is an abnormality of brain development characterized by incomplete neuronal migration and a smooth cerebral surface, resulting in severe mental retardation. Genetic analysis identified two proteins that are mutated in some cases of lissencephaly, designated lissencephaly-1 protein (LIS1) and doublecortin. LIS1 shows sequence homology to b-subunits of heterotrimeric G proteins. Doublecortin contains a consensus Abl phosphorylation site, and it has some sequence homology to a predicted kinase protein. Both proteins are highly expressed in developing brain, suggesting that they may be involved in a signal transduction pathway that is crucial to brain development.
Alexa Fluor® est une marque déposée de Molecular Probes Inc., OR., USA
LI-COR® et Odyssey® sont marques déposées de LI-COR Biosciences
Informations pour la commande
Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps LIS1 (C-7) | sc-393320 | 200 µg/ml | $316.00 | |||
LIS1 (C-7): m-IgG Fc BP-HRP Kit | sc-538188 | 200 µg Ab; 10 µg BP | $354.00 | |||
LIS1 (C-7): m-IgGκ BP-HRP Kit | sc-535752 | 200 µg Ab; 40 µg BP | $354.00 | |||
LIS1 (C-7): m-IgG1 BP-HRP Kit | sc-545565 | 200 µg Ab; 20 µg BP | $354.00 |