LAMP1 Antibody (E-5): sc-17768
- LAMP1 Antibody (E-5) is a mouse monoclonal IgG2a κ, cited in 94 publications, provided at 200 µg/ml
- raised against amino acids 1-228 of LAMP-1 of human origin
- Anti-LAMP1 Antibody (E-5) is recommended for detection of LAMP-1 of mouse, rat and human origin by WB, IP, IF and IHC(P)
- Anti-LAMP1 Antibody (E-5) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG2a BP-HRP are the preferred secondary detection reagents for LAMP1 Antibody (E-5) for WB and IHC(P) applications. These reagents are now offered in bundles with LAMP1 Antibody (E-5) (see ordering information below).
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LAMP-1 Antibody (E-5) is a mouse monoclonal IgG2a kappa light chain antibody that detects LAMP-1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. Anti-LAMP-1 antibody (E-5) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. LAMP-1, also known as CD107a, is a glycosylated type I membrane protein primarily located on the lysosomal membrane, where LAMP-1 plays a crucial role in maintaining lysosomal integrity and function. LAMP-1 is essential for the proper degradation of cellular waste and the recycling of cellular components, which is vital for cellular homeostasis. Additionally, LAMP-1 is involved in the process of cellular adhesion and contributes to tumor invasion and metastasis, highlighting LAMP-1′s importance in both normal physiology and disease states. LAMP-1 expression is notably increased in lysosomal storage disorders, indicating LAMP-1′s potential as a biomarker for these conditions. LAMP-1 monoclonal antibody (E-5) enables researchers to gain insights into the roles of lysosomal proteins in various biological processes and disease mechanisms.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
LAMP1 Antibody (E-5) References:
- LAMP-1 and LAMP-2, but not LAMP-3, are reliable markers for activation-induced secretion of human mast cells. | Grützkau, A., et al. 2004. Cytometry A. 61: 62-8. PMID: 15351990
- Roles of LAMP-1 and LAMP-2 in lysosome biogenesis and autophagy. | Eskelinen, EL. 2006. Mol Aspects Med. 27: 495-502. PMID: 16973206
- Fucosylation of LAMP-1 and LAMP-2 by FUT1 correlates with lysosomal positioning and autophagic flux of breast cancer cells. | Tan, KP., et al. 2016. Cell Death Dis. 7: e2347. PMID: 27560716
- Lysosome-associated membrane proteins-1 and -2 (LAMP-1 and LAMP-2) assemble via distinct modes. | Terasawa, K., et al. 2016. Biochem Biophys Res Commun. 479: 489-495. PMID: 27663661
- LAMP-1 gene is overexpressed in high grade glioma. | Sarafian, VS., et al. 2018. APMIS. 126: 657-662. PMID: 29920782
- The Major Lysosomal Membrane Proteins LAMP-1 and LAMP-2 Participate in Differentiation of C2C12 Myoblasts. | Sakane, H. and Akasaki, K. 2018. Biol Pharm Bull. 41: 1186-1193. PMID: 30068868
- CD107a+ (LAMP-1) Cytotoxic CD8+ T-Cells in Lupus Nephritis Patients. | Wiechmann, A., et al. 2021. Front Med (Lausanne). 8: 556776. PMID: 33834029
- LAMP-1 Chimeric to HIV-1 p55Gag in the Immunization of Neonate Mice Induces an Early Germinal Center Formation and AID Expression. | Teixeira, FME., et al. 2022. Vaccines (Basel). 10: PMID: 36016134
- Deciphering cross-species reactivity of LAMP-1 antibodies using deep mutational epitope mapping and AlphaFold. | Pruvost, T., et al. 2023. MAbs. 15: 2175311. PMID: 36797224
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
LAMP1 Antibody (E-5) | sc-17768 | 200 µg/ml | $322.00 | |||
LAMP1 Antibody (E-5): m-IgG Fc BP-HRP Bundle | sc-525484 | 200 µg Ab; 10 µg BP | $361.00 | |||
LAMP1 Antibody (E-5): m-IgG2a BP-HRP Bundle | sc-546280 | 200 µg Ab; 10 µg BP | $361.00 | |||
LAMP1 Antibody (E-5) AC | sc-17768 AC | 500 µg/ml, 25% agarose | $424.00 | |||
LAMP1 Antibody (E-5) HRP | sc-17768 HRP | 200 µg/ml | $322.00 | |||
LAMP1 Antibody (E-5) FITC | sc-17768 FITC | 200 µg/ml | $336.00 | |||
LAMP1 Antibody (E-5) PE | sc-17768 PE | 200 µg/ml | $349.00 | |||
LAMP1 Antibody (E-5) Alexa Fluor® 488 | sc-17768 AF488 | 200 µg/ml | $364.00 | |||
LAMP1 Antibody (E-5) Alexa Fluor® 546 | sc-17768 AF546 | 200 µg/ml | $364.00 | |||
LAMP1 Antibody (E-5) Alexa Fluor® 594 | sc-17768 AF594 | 200 µg/ml | $364.00 | |||
LAMP1 Antibody (E-5) Alexa Fluor® 647 | sc-17768 AF647 | 200 µg/ml | $364.00 | |||
LAMP1 Antibody (E-5) Alexa Fluor® 680 | sc-17768 AF680 | 200 µg/ml | $364.00 | |||
LAMP1 Antibody (E-5) Alexa Fluor® 790 | sc-17768 AF790 | 200 µg/ml | $364.00 |