KU-0058948 (CAS 763111-49-5)
Alternate Names:
PARP1 inhibitor
Application:
KU-0058948 is a PARP (poly (ADP-ribose) polymerase) inhibitor.
CAS Number:
763111-49-5
Molecular Weight:
380.42
Molecular Formula:
C21H21FN4O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
KU-0058948 is a PARP (poly (ADP-ribose) polymerase) inhibitor. Studies show that KU-0058948 is a potent agonist that activates transfected MAPK15 (extracellular signal-regulated kinase 8, ERK8) in cells. KU-0058948 induces cell cycle arrest and apoptosis of primary myeloid leukemic cells and myeloid leukemic cell lines in vitro.
KU-0058948 (CAS 763111-49-5) References
- Poly(ADP-ribose)-binding zinc finger motifs in DNA repair/checkpoint proteins. | Ahel, I., et al. 2008. Nature. 451: 81-5. PMID: 18172500
- The histone subcode: poly(ADP-ribose) polymerase-1 (Parp-1) and Parp-2 control cell differentiation by regulating the transcriptional intermediary factor TIF1beta and the heterochromatin protein HP1alpha. | Quénet, D., et al. 2008. FASEB J. 22: 3853-65. PMID: 18676401
- Chromosomal instability syndromes are sensitive to poly ADP-ribose polymerase inhibitors. | Gaymes, TJ., et al. 2008. Haematologica. 93: 1886-9. PMID: 18838476
- Regulation of the activity and expression of ERK8 by DNA damage. | Klevernic, IV., et al. 2009. FEBS Lett. 583: 680-4. PMID: 19166846
- XRCC1 interacts with the p58 subunit of DNA Pol alpha-primase and may coordinate DNA repair and replication during S phase. | Lévy, N., et al. 2009. Nucleic Acids Res. 37: 3177-88. PMID: 19305001
- Parp2 is required for the differentiation of post-meiotic germ cells: identification of a spermatid-specific complex containing Parp1, Parp2, TP2 and HSPA2. | Quénet, D., et al. 2009. Exp Cell Res. 315: 2824-34. PMID: 19607827
- A chromatin localization screen reveals poly (ADP ribose)-regulated recruitment of the repressive polycomb and NuRD complexes to sites of DNA damage. | Chou, DM., et al. 2010. Proc Natl Acad Sci U S A. 107: 18475-80. PMID: 20937877
- Poly(ADP-ribose) polymerase 3 (PARP3), a newcomer in cellular response to DNA damage and mitotic progression. | Boehler, C., et al. 2011. Proc Natl Acad Sci U S A. 108: 2783-8. PMID: 21270334
- DNA damage in Nijmegen Breakage Syndrome cells leads to PARP hyperactivation and increased oxidative stress. | Krenzlin, H., et al. 2012. PLoS Genet. 8: e1002557. PMID: 22396666
- Combinatorial effects of PARP inhibitor PJ34 and histone deacetylase inhibitor vorinostat on leukemia cell lines. | Jasek, E., et al. 2014. Anticancer Res. 34: 1849-56. PMID: 24692719
- Damage-induced BRCA1 phosphorylation by Chk2 contributes to the timing of end resection. | Parameswaran, B., et al. 2015. Cell Cycle. 14: 437-48. PMID: 25659039
- Diadenosine 5', 5'''-P(1),P(4)-tetraphosphate (Ap4A) is synthesized in response to DNA damage and inhibits the initiation of DNA replication. | Marriott, AS., et al. 2015. DNA Repair (Amst). 33: 90-100. PMID: 26204256
- NUDT2 Disruption Elevates Diadenosine Tetraphosphate (Ap4A) and Down-Regulates Immune Response and Cancer Promotion Genes. | Marriott, AS., et al. 2016. PLoS One. 11: e0154674. PMID: 27144453
- PARP3, a new therapeutic target to alter Rictor/mTORC2 signaling and tumor progression in BRCA1-associated cancers. | Beck, C., et al. 2019. Cell Death Differ. 26: 1615-1630. PMID: 30442946
- Inhibitors of poly ADP-ribose polymerase (PARP) induce apoptosis of myeloid leukemic cells: potential for therapy of myeloid leukemia and myelodysplastic syndromes. | Gaymes, TJ., et al. 2021. Haematologica. 106: 2294. PMID: 34333961
Inhibitor of:
PARP.Activator of:
ERK, and MAPK15.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
KU-0058948, 10 mg | sc-489065 | 10 mg | $560.00 |