Small guanosine triphosphatases, typified by the mammalian Ras proteins, play major roles in the regulation of numerous cellular pathways. IκB-interacting Ras-like proteins, κB-Ras1 and κB-Ras2, belong to a subclass of evolutionarily conserved Ras-like proteins that differ from other Ras proteins in containing amino acids at positions 12 and 61 that are similar to those present in the oncogenic forms of Ras. These Ras-like proteins, κB-Ras1 and κB-Ras2, interact with the PEST domains of IκBα and IκBβ and decrease their rate of degradation. κB-Ras2 shows 71% identity to κB-Ras1. In cells, κB-Ras proteins are associated only with NFκB:IκBβ complexes and therefore may provide an explanation for the slower rate of degradation of IκBβ compared with IκBα.
Informations pour la commande
Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps κB-Ras1 (C-7) | sc-398511 | 200 µg/ml | $316.00 | |||
κB-Ras1 (C-7): m-IgG Fc BP-HRP Kit | sc-538461 | 200 µg Ab; 10 µg BP | $354.00 | |||
κB-Ras1 (C-7): m-IgGκ BP-HRP Kit | sc-536082 | 200 µg Ab; 40 µg BP | $354.00 | |||
κB-Ras1 (C-7): m-IgG1 BP-HRP Kit | sc-545713 | 200 µg Ab; 20 µg BP | $354.00 |