ITI-H5 (inter-alpha (globulin) inhibitor H5), also known as inter-alpha-trypsin inhibitor heavy chain H5, is a 942 amino acid protein belonging to the ITIH family. Encoded by a gene that maps to human chromosome 10p14, ITI-H5 is differentially expressed in human breast tumor and ovary tissues, with highest levels in placenta. Existing as four alternatively spliced isoforms, ITI-H5 is composed of multipolypeptides, possibly including one heavy chain containing potential calcium-binding sites and two light chains. ITI-H5 encodes a heavy chain component of one of the inter-alpha-trypsin inhibitor family members and participates in extracellular matrix stabilization, tumor metastasis prevention and plasma serine protease inhibition. ITI-H5 consists of two conserved ITIH domains: a vault inter-alpha-trypsin (VIT) domain and a von Willebrand type A (VWA) domain. Decreased expression of ITI-H5 may be involved in various tumor and breast cancer development.
Informations pour la commande
Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps ITI-H5 (B-7) | sc-398538 | 200 µg/ml | $316.00 | |||
ITI-H5 (B-7): m-IgG Fc BP-HRP Kit | sc-540940 | 200 µg Ab; 10 µg BP | $354.00 | |||
ITI-H5 (B-7): m-IgG1 BP-HRP Kit | sc-542476 | 200 µg Ab; 20 µg BP | $354.00 |