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Trefoil peptides are protease resistant molecules secreted throughout the gut that play a role in mucosal healing. Trefoil peptides contain three intrachain disulfide bonds, forming the trefoil motif, or P-domain. ITF (intestinal trefoil factor) is expressed in the epithelial mucosal layer of the small intestine and colon, brain and pituitary. SP (also known as pancreatic trefoil factor 2 or pancreatic spasmolytic polypeptide) is an inhibitor of spasmolytic activity and gastric acid secretion. Human SP is expressed exclusively in normal stomach epithelium and unlike pS2, it is not expressed in breast carcinoma. Both SP and ITF are predominantly found in gastrointestinal tissues, and are upregulated around areas of epithelial damage and in meta- and neoplasia. The genes which encode pS2, SP and ITF are clustered in human chromosome 21q22.3.
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Informations pour la commande
Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps ITF (H-425) | sc-81954 | 100 µg/ml | $333.00 |