Anticorps IRF-1 (20): sc-135952
- L'anticorps IRF-1 20 est un monoclonal IgG1 de souris, cité dans 2 publications, fourni en 50 µg/0.5 ml
- dirigé contre les acides aminés 159-279 de IRF-1 d'origine human
- recommandé pour la détection de IRF-1 d'origine human par WB et IP
- Voir IRF-1 (E-4): sc-514544 pour d'autres anticorps conjugués IRF-1, dont AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 et 790.
- Nous testons actuellement encore nos anticorps secondaires pour trouver la meilleure protéine de liaison pour cet anticorps primaire IRF-1 (20). Veuillez nous contacter si vous avez des questions concernant les réactifs de détection secondaire appropriés.
Interferon regulatory factor-1 (IRF-1) and IRF-2 have been identified as novel DNA-binding factors that function as regulators of both type I interferon (interferon-α and β) and interferon-inducible genes. The two factors are structurally related, particularly in their N-terminal regions, which confer DNA binding specificity. In addition, both bind to the same sequence within the promoters of interferon-α and interferon-β genes. IRF-1 functions as an activator of interferon transcription, while IRF-2 binds to the same cis elements and represses IRF-1 action. IRF-1 and IRF-2 have been reported to act in a mutually antagonistic manner in regulating cell growth; overexpression of the repressor IRF-2 leads to cell transformation while concomitant overexpression of IRF-1 causes reversion. IRF-1 and IRF-2 are members of a larger family of DNA binding proteins that includes IRF-3, IRF-4, IRF-5, IRF-6, IRF-7, ISGF-3γ p48 (a component of the ISGF-3 complex) and IFN consensus sequence-binding protein (ICSBP).
Informations pour la commande
| Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps IRF-1 (20) | sc-135952 | 50 µg/0.5 ml | $316.00 |