involucrin Antibody (A-5): sc-398952
- involucrin Antibody (A-5) is a mouse monoclonal IgG1 κ, cited in 5 publications, provided at 200 µg/ml
- raised against amino acids 1-120 mapping at the N-terminus of involucrin of human origin
- recommended for detection of involucrin of mouse, rat and human origin by WB, IP, IF and ELISA
- See involucrin (SY5): sc-21748 for involucrin antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for involucrin Antibody (A-5) for WB applications. These reagents are now offered in bundles with involucrin Antibody (A-5) (see ordering information below).
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Involucrin Antibody (A-5) is a mouse monoclonal IgG1 antibody that detects involucrin in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Involucrin plays a crucial role in the formation of the keratinocyte cornified envelope, a vital structure that provides a barrier to protect underlying tissues from environmental damage. Involucrin is initially located in the cytosol of keratinocytes and is subsequently cross-linked to membrane proteins by transglutaminase during terminal differentiation. The significance of involucrin lies in its ability to form covalent ε-(γ-glutamyl) lysine bonds with other envelope precursors, which is essential for the structural integrity and functionality of the cornified envelope. The large size of involucrin enables multiple cross-links across considerable distances, facilitating the formation of a robust and resilient barrier. Involucrin is specifically expressed in various cell types, including Chinese hamster ovarian cells, PtK2 rat kangaroo kidney cells, and rat epidermal keratinocytes, highlighting its importance in epithelial tissue development and maintenance. Anti-involucrin antibody (A-5) is an invaluable tool for researchers studying skin biology, keratinocyte differentiation, and related pathologies.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
involucrin Antibody (A-5) | sc-398952 | 200 µg/ml | $322.00 | |||
involucrin Antibody (A-5): m-IgG Fc BP-HRP Bundle | sc-538550 | 200 µg Ab; 10 µg BP | $361.00 | |||
involucrin Antibody (A-5): m-IgGκ BP-HRP Bundle | sc-536186 | 200 µg Ab; 40 µg BP | $361.00 | |||
involucrin Antibody (A-5): m-IgG1 BP-HRP Bundle | sc-545760 | 200 µg Ab; 20 µg BP | $361.00 |