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Int-6, also designated eIF3e, eIF3-p46, eIF3-p48 and eukaryotic translation initiation factor 3, subunit 6, regulates translation and protein degradation through binding with three complexes: the eukaryotic translation initiation factor 3 (eIF3), the proteasome regulatory lid and the constitutive photomorphogenesis 9 signalosome. eIF3 is a complex that mediates assembly of 40S ribosomal subunits on mRNA bearing either a 5'-cap or an internal ribosome entry site (IRES). The Int-6 gene is a site of mouse mammary tumour virus (MMTV) integration in murine tumors. Reducing Int-6 expression by RNA interference in HeLa cells alters mitosis progression through defects in spindle formation, chromosome segregation and cytokinesis. These abberations appear to correlate with an inhibition of cyclin B-Cdk1 kinase activity, due to a protracted inhibitory phosphorylated state of Cdk1.
Informations pour la commande
Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps Int-6 (H-6) | sc-376109 | 200 µg/ml | $316.00 | |||
Int-6 (H-6): m-IgG Fc BP-HRP Kit | sc-537966 | 200 µg Ab; 10 µg BP | $354.00 | |||
Int-6 (H-6): m-IgGκ BP-HRP Kit | sc-535461 | 200 µg Ab; 40 µg BP | $354.00 | |||
Int-6 (H-6): m-IgG2b BP-HRP Kit | sc-549903 | 200 µg Ab; 10 µg BP | $354.00 | |||
Int-6 (H-6) peptide neutralisant | sc-376109 P | 100 µg/0.5 ml | $68.00 |