Leukocyte immunoglobulin-like receptors (ILTs, also known as LIRs) are members of the immunoglobulin superfamily of glycoproteins and are predominantly expressed by monocytes, B cells, dendritic cells, natural killer (NK) cells, peripheral blood leukocytes and tissues such as placenta, lung and liver. There are several members of the ILT family, including ILT-1, ILT-2, ILT-3, ILT-4, ILT-5, ILT-6, ILT-7, ILT-8, ILT-11, LIR-6 and LIR-8. These ILT proteins are divided into two subfamiles, namely subfamily A (ILT-1, ILT-6, ILT-7, ILT-8, ILT-11 and LIR-6) and subfamily B (ILT-2, ILT-3, ILT-4, ILT-5 and LIR-8), the former of which function as stimulating receptors and the latter of which function as inhibitory receptors. Characteristically, members of subfamily A have transmembrane regions containing a charged arginine residue through which they initiate stimulatory cascades, while members of subfamily B contain cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs) through which they induce inhibitory signaling cascades.
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Informations pour la commande
Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps ILT (A-9) | sc-166580 | 200 µg/ml | $316.00 | |||
ILT (A-9): m-IgG Fc BP-HRP Kit | sc-540124 | 200 µg Ab; 10 µg BP | $354.00 | |||
ILT (A-9): m-IgG1 BP-HRP Kit | sc-541918 | 200 µg Ab; 20 µg BP | $354.00 |