IL-13 Antibody (JES10-2E10): sc-52564

IL-13 Antibody (JES10-2E10) is a rat monoclonal IgG1 antibody that detects interleukin-13 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-IL-13 antibody (JES10-2E10) plays a crucial role in understanding the function of interleukin-13, a pleiotropic cytokine that is integral to immune regulation and inflammation. This cytokine is primarily secreted by activated T lymphocytes and is known for modulating the activity of monocytes, macrophages, and B cells, thereby influencing the immune response. Interleukin-13 shares significant sequence identity with interleukin-4 and exhibits overlapping biological activities, such as upregulating the expression of CD23 and MHC proteins while downregulating CD14. These actions are vital for the regulation of IgE production in B cells and the inhibition of proinflammatory cytokines from activated monocytes, making interleukin-13 a key player in allergic responses and asthma pathogenesis. The protein′s structure includes five cysteine residues and multiple N-linked glycosylation sites, which are essential for stability and function. The cDNA of interleukin-13 encodes a 131 amino acid precursor that includes a 20 amino acid signal peptide, which is cleaved to produce the mature protein. IL-13 monoclonal antibody (JES10-2E10) is an invaluable tool for researchers studying the complex roles of interleukin-13 in various biological processes and diseases.

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IL-13 Antibody (JES10-2E10) References:

1. IL-4/IL-13 signaling beyond JAK/STAT.  |  Jiang, H., et al. 2000. J Allergy Clin Immunol. 105: 1063-70. PMID: 10856136
2. Targeting of IL-4 and IL-13 receptors for cancer therapy.  |  Suzuki, A., et al. 2015. Cytokine. 75: 79-88. PMID: 26088753
3. IL-13 antagonists in the treatment of atopic dermatitis.  |  Tubau, C. and Puig, L. 2021. Immunotherapy. 13: 327-344. PMID: 33430628
4. Involvement of IL-4, IL-13 and Their Receptors in Pancreatic Cancer.  |  Shi, J., et al. 2021. Int J Mol Sci. 22: PMID: 33804263
5. IL-4/IL-13 axis as therapeutic targets in allergic rhinitis and asthma.  |  Nur Husna, SM., et al. 2022. PeerJ. 10: e13444. PMID: 35663523
6. The IL-4/IL-13 signaling axis promotes prostatic fibrosis.  |  D'Arcy, Q., et al. 2022. PLoS One. 17: e0275064. PMID: 36201508
7. IL-13-associated epithelial remodeling correlates with clinical severity in nasal polyposis.  |  Kotas, ME., et al. 2023. J Allergy Clin Immunol. 151: 1277-1285. PMID: 36736797
8. Interleukin-13 (IL-13)-A Pleiotropic Cytokine Involved in Wound Healing and Fibrosis.  |  Roeb, E. 2023. Int J Mol Sci. 24: PMID: 37629063
9. Roles of IL-4, IL-13, and Their Receptors in Lung Cancer.  |  Zhang, Y., et al. 2024. J Interferon Cytokine Res. 44: 399-407. PMID: 38516928
10. Targeting IL-13 with tralokinumab normalizes type 2 inflammation in atopic dermatitis both early and at 2 years.  |  Guttman-Yassky, E., et al. 2024. Allergy. 79: 1560-1572. PMID: 38563683

The preferred IL-13 antibody is IL-13 Antibody (A-9): sc-393365.