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The pleiotropic cytokine, IL-11, has been shown to have proliferative and differentiation effects on lymphopoietic, myeloid and erythroid cells. IL-11 also has the inhibiting effect of repressing adipogenesis in vitro. The IL-11α receptor, IL-11Rα, is a member of the class I subgroup of the cytokine receptor family and exhibits structural similarity to the a subunits of the human ciliary neurotrophic factor (CNTF) and the mouse IL-6 receptor. It is speculated that the IL-11Rα regulates the proliferation and/or differentiation of skeletogenic progenitor and mesenchymal cells. Coexpression of gp130 and IL-11α is necessary for high affinity binding of IL-11 to IL-11Rα. It has also been found that coexpression of IL-11Rα and gp130 is required for proper stimulation of Ba/F3 cells to differentiate into macrophage in response to IL-11.
Informations pour la commande
Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps IL-11Rα (H-3) | sc-393227 | 200 µg/ml | $316.00 | |||
IL-11Rα (H-3): m-IgG Fc BP-HRP Kit | sc-538171 | 200 µg Ab; 10 µg BP | $354.00 | |||
IL-11Rα (H-3): m-IgGκ BP-HRP Kit | sc-535731 | 200 µg Ab; 40 µg BP | $354.00 | |||
IL-11Rα (H-3): m-IgG2a BP-HRP Kit | sc-548224 | 200 µg Ab; 10 µg BP | $354.00 | |||
IL-11Rα (H-3) peptide neutralisant | sc-393227 P | 100 µg/0.5 ml | $68.00 |