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Interleukin-11, or IL-11, is a pleiotropic cytokine that is biologically related to IL-6, leukemia inhibitory factor (LIF), oncostatin M (OSM) and ciliary neurotrophic factor (CNTF). IL-11 is a stromal cell-derived cytokine which stimulates the proliferation of primitive hematopoietic progenitor cells and, together with Flt 3-L, stimulates the expansion of CD34+ cell populations. Human IL-11 cDNA encodes a 199 amino acid precursor with a 21 amino acid hydrophobic signal peptide which is cleaved to generate a glycosylated biologically active form. IL-11 exerts its biological effects through the interleukin-11 receptor, IL-11R, which is composed of an IL-11 receptor-specific chain designated IL-11Rα, and gp130, the signal transducing component common to the IL-6, LIF, OSM and CNTF receptors. Stimulation of the IL-11R results in the activation of the Janus tyrosine kinase family members JAK1 and JAK2 which, once activated, induce the nuclear translocation of the transcription factors Stat1 and Stat3.
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Informations pour la commande
Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps IL-11 (F-3) | sc-133084 | 200 µg/ml | $316.00 | |||
IL-11 (F-3): m-IgG Fc BP-HRP Kit | sc-539846 | 200 µg Ab; 10 µg BP | $354.00 | |||
IL-11 (F-3): m-IgG2a BP-HRP Kit | sc-546797 | 200 µg Ab; 10 µg BP | $354.00 |