IKK alpha Antibody (61AT277): sc-130153
- IKK alpha Antibody (61AT277) is a mouse monoclonal IgG1, cited in 1 publications, provided at 100 µg/ml
- raised against full-length recombinant IKKα of human origin
- recommended for detection of IKKα of human origin by WB, IP and ELISA
- See IKK alpha (B-8): sc-7606 for IKK alpha antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for IKK alpha Antibody (61AT277). This work is in progress.
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IKKα Antibody (61AT277) is a mouse monoclonal IgG1 antibody that detects IKKα in human samples through applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). IKKα, also known as IκB kinase α, plays a pivotal role in the NFκB signaling pathway, which is crucial for regulating immune responses, inflammation, and cell survival. IKKα is primarily located in the cytoplasm, where IKKα interacts with the inhibitory protein IκB to facilitate the phosphorylation and subsequent degradation of IκB, thereby allowing the activation and translocation of NFκB to the nucleus. The proper functioning of IKKα is essential for the cellular response to proinflammatory cytokines, as IKKα is stimulated by the NFκB inducing kinase (NIK), which acts as a central regulator in this pathway. The IKK complex, which includes IKKα, IKKβ, and IKKγ (NEMO), is vital for the phosphorylation of IκB, and any dysregulation in this process can lead to various inflammatory diseases and cancers. Anti-IKKα antibody (61AT277) is an invaluable tool for researchers studying the intricate mechanisms of NFκB activation and its implications in human health and disease.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
IKK alpha Antibody (61AT277) References:
- IKIP Negatively Regulates NF-κB Activation and Inflammation through Inhibition of IKKα/β Phosphorylation. | Wu, H., et al. 2020. J Immunol. 204: 418-427. PMID: 31826938
- Enterovirus 2C Protein Suppresses IKKα Phosphorylation by Recruiting IKKβ and IKKα into Viral Inclusion Bodies. | Ji, L., et al. 2021. Viral Immunol. 34: 218-226. PMID: 33226912
- The inflammatory kinase IKKα phosphorylates and stabilizes c-Myc and enhances its activity. | Moser, B., et al. 2021. Mol Cancer. 20: 16. PMID: 33461590
- Diabetes Mellitus Promotes Atrial Structural Remodeling and PARP-1/Ikkα/NF-κB Pathway Activation in Mice. | Meng, T., et al. 2021. Diabetes Metab Syndr Obes. 14: 2189-2199. PMID: 34040405
- IKKα mediates UVB-induced cell apoptosis by regulating p53 pathway activation. | Wang, H., et al. 2021. Ecotoxicol Environ Saf. 227: 112892. PMID: 34649141
- Extracellular HSP90α Induces MyD88-IRAK Complex-Associated IKKα/β-NF-κB/IRF3 and JAK2/TYK2-STAT-3 Signaling in Macrophages for Tumor-Promoting M2-Polarization. | Fan, CS., et al. 2022. Cells. 11: PMID: 35053345
- EPO activates PI3K-IKKα-CDK1 signaling pathway to promote the proliferation of Glial Cells under hypoxia environment. | Hu, G., et al. 2022. Genet Mol Biol. 45: e20210249. PMID: 35167649
- Spatial expression of IKK-alpha is associated with a differential mutational landscape and survival in primary colorectal cancer. | Patel, M., et al. 2022. Br J Cancer. 126: 1704-1714. PMID: 35173303
- IKKα promotes lung adenocarcinoma growth through ERK signaling activation via DARPP-32-mediated inhibition of PP1 activity. | Alam, SK., et al. 2023. NPJ Precis Oncol. 7: 33. PMID: 36966223
- IKKα inhibition re-sensitizes acquired adriamycin-resistant triple negative breast cancer cells to chemotherapy-induced apoptosis. | Liao, J., et al. 2023. Sci Rep. 13: 6211. PMID: 37069240
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
IKK alpha Antibody (61AT277) | sc-130153 | 100 µg/ml | $322.00 |