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The basic structural unit of most mammalian antibodies is a glycoprotein composed of four polypeptide chains - two light chains, and two heavy chains, which are connected by disulfide bonds. Each light chain is composed of two domains, one variable domain (VL) and one constant domain (CL). The variable region genes encoding immunoglobulin κ and λ chains are assembled from three DNA segments, the V, C and J genes. Human κ light chain genes map to chromosome 2 and the human λ light chain genes map to chromosome 22. κ gene recombination can precede λ gene recombination during B-cell ontogeny and only a single light chain type is expressed in individual B cells.
Informations pour la commande
Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps IgG light chain (SB62a ) | sc-69831 | 100 µg/ml | $316.00 |