ICOS Antibody (27A12): sc-53028
- ICOS Antibody (27A12) is a Syrian hamster monoclonal IgM provided at 200 µg/ml
- raised against the extracellular domain of ICOS of mouse origin
- recommended for detection of ICOS of mouse origin by FCM
- available conjugated to either phycoerythrin or FITC for IF, IHC(P) and FCM
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for ICOS Antibody (27A12). This work is in progress.
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ICOS Antibody (27A12) is a hamster monoclonal IgM antibody that detects ICOS in mouse samples through flow cytometry (FCM). ICOS, or inducible co-stimulator, plays a crucial role in the immune response by enhancing T cell activation and promoting the production of interleukin-10, a cytokine that helps regulate immune responses and maintain tolerance. ICOS is primarily expressed on activated T cells and is essential for the development of effective immune responses, particularly in the context of T cell interactions with antigen-presenting cells. Anti-ICOS antibody (27A12) enables researchers to study ICOS′s ability to fine-tune T cell activity, ensuring that the immune system can respond robustly to pathogens while preventing excessive inflammation that could lead to tissue damage. ICOS monoclonal antibody (27A12) provides valuable insights into T cell dynamics and the mechanisms underlying immune regulation, making this tool indispensable for studies focused on immunology and therapeutic interventions.
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ICOS Antibody (27A12) References:
- ICOS:ICOS-ligand interaction is required for type 2 innate lymphoid cell function, homeostasis, and induction of airway hyperreactivity. | Maazi, H., et al. 2015. Immunity. 42: 538-51. PMID: 25769613
- IL-6 and ICOS Antagonize Bim and Promote Regulatory T Cell Accrual with Age. | Raynor, J., et al. 2015. J Immunol. 195: 944-52. PMID: 26109645
- ICOS-Ligand Triggering Impairs Osteoclast Differentiation and Function In Vitro and In Vivo. | Gigliotti, CL., et al. 2016. J Immunol. 197: 3905-3916. PMID: 27798154
- Protective Role of ICOS and ICOS Ligand in Corneal Transplantation and in Maintenance of Immune Privilege. | Kunishige, T., et al. 2016. Invest Ophthalmol Vis Sci. 57: 6815-6823. PMID: 28002569
- ICOS Signaling Controls Induction and Maintenance of Collagen-Induced Arthritis. | Panneton, V., et al. 2018. J Immunol. 200: 3067-3076. PMID: 29581356
- ICOS deficiency hampers the homeostasis, development and function of NK cells. | Montes-Casado, M., et al. 2019. PLoS One. 14: e0219449. PMID: 31283790
- The ubiquitin ligase Peli1 inhibits ICOS and thereby Tfh-mediated immunity. | Huang, X., et al. 2021. Cell Mol Immunol. 18: 969-978. PMID: 33707688
- ICOS ligand and IL-10 synergize to promote host-microbiota mutualism. | Landuyt, AE., et al. 2021. Proc Natl Acad Sci U S A. 118: PMID: 33753483
- Acazicolcept (ALPN-101), a dual ICOS/CD28 antagonist, demonstrates efficacy in systemic sclerosis preclinical mouse models. | Orvain, C., et al. 2022. Arthritis Res Ther. 24: 13. PMID: 34986869
- Tumor-infiltrating mast cells stimulate ICOS+ regulatory T cells through an IL-33 and IL-2 axis to promote gastric cancer progression. | Lv, Y., et al. 2024. J Adv Res. 57: 149-162. PMID: 37086778
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ICOS Antibody (27A12) | sc-53028 | 200 µg/ml | $322.00 | |||
ICOS Antibody (27A12) FITC | sc-53028 FITC | 200 µg/ml | $336.00 | |||
ICOS Antibody (27A12) PE | sc-53028 PE | 200 µg/ml | $349.00 |