HXK I Antibody (A-2): sc-390517

HXK I Antibody (A-2) is a mouse monoclonal IgG1 antibody that detects hexokinase I in mouse and rat samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-hexokinase I antibody (A-2) plays a crucial role in understanding the function of hexokinase I, which is essential for glucose metabolism as it catalyzes the conversion of glucose to glucose-6-phosphate, the first step in the glycolytic pathway. This process is vital for energy production and metabolic regulation in various tissues, including the brain, kidney, and heart, where hexokinase I is predominantly expressed. Hexokinase I (A-2) monoclonal antibody facilitates research into glucose homeostasis by enabling studies of glucose uptake and utilization, especially in response to physiological demands. Additionally, hexokinase I′s interaction with other proteins and regulatory mechanisms can provide insights into metabolic disorders, making anti-hexokinase I antibody (A-2) an invaluable tool for researchers studying glucose metabolism and related diseases.

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HXK I Antibody (A-2) References:

1. Optimization and Evaluation of Antiparasitic Benzamidobenzoic Acids as Inhibitors of Kinetoplastid Hexokinase 1.  |  Flaherty, DP., et al. 2017. ChemMedChem. 12: 1994-2005. PMID: 29105342
2. Hexokinase 2 is targetable for HK1 negative, HK2 positive tumors from a wide variety of tissues of origin.  |  Xu, S., et al. 2018. J Nucl Med. 60: 212-7. PMID: 29880505
3. An HK2 Antisense Oligonucleotide Induces Synthetic Lethality in HK1-HK2+ Multiple Myeloma.  |  Xu, S., et al. 2019. Cancer Res. 79: 2748-2760. PMID: 30885978
4. Overexpression of Protein Phosphatase 2 Regulatory Subunit B'Alpha Promotes Glycolysis by Regulating Hexokinase 1 in Hepatocellular Carcinoma.  |  Jiao, N., et al. 2022. Biomed Environ Sci. 35: 622-632. PMID: 35945177
5. Transcription factor TERF1 promotes seed germination through HEXOKINASE 1 (HXK1)-mediated signaling pathway.  |  Yuan, L., et al. 2023. J Plant Res. 136: 743-753. PMID: 37233958
6. Intermittent Hypoxia Promotes TAM-Induced Glycolysis in Laryngeal Cancer Cells via Regulation of HK1 Expression through Activation of ZBTB10.  |  Yang, M., et al. 2023. Int J Mol Sci. 24: PMID: 37834257
7. 5'-tRF-19-Q1Q89PJZ Suppresses the Proliferation and Metastasis of Pancreatic Cancer Cells via Regulating Hexokinase 1-Mediated Glycolysis.  |  Cao, W., et al. 2023. Biomolecules. 13: PMID: 37892195
8. Regulation of macrophage polarization and glucose metabolism by the ERK/MAPK-HK1 signaling pathway in paraquat-induced acute lung injury.  |  Li, M., et al. 2024. Chem Biol Interact. 397: 111062. PMID: 38763349
9. Regional mapping of the locus for hexokinase-1 (HK1) to 10p11 equals to q23 by gene dosage in human fibroblasts.  |  Gitelman, BJ. and Simpson, NE. 1982. Hum Genet. 60: 227-9. PMID: 7106753
10. Mouse spermatogenic cell-specific type 1 hexokinase (mHk1-s) transcripts are expressed by alternative splicing from the mHk1 gene and the HK1-S protein is localized mainly in the sperm tail.  |  Mori, C., et al. 1998. Mol Reprod Dev. 49: 374-85. PMID: 9508088

The preferred HXK I antibody is HXK I Antibody (G-1): sc-46695.