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VOIR ÉGALEMENT...
The infected cell protein 0 (ICP0) is a general transactivator of all three classes of herpes simplex virus (HSV) genes. ICP0 functions synergistically with ICP4 and may control the balance between the latent and lytic states by reactivating latent HSV. A short sequence of ICP0 is similar to a sequence in the N-terminus of CoREST, a corepressor that exists in complexes with histone deacetylases (HDACs) 1 or 2 and the repressor REST. ICP0 is required to replicate HSV as well as enable gene expression and precludes the silencing of viral DNA by disrupting the human BHC corepressor complex though its interaction with human RCOR1/CoREST protein. ICP0 also interacts with and leads to the degradation of the human centromere protein CENP-A.
Informations pour la commande
Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps HSV-1 ICP0 (5H7) | sc-56985 | 100 µg/ml | $316.00 |