The Hox homeobox genes encode proteins that are transcriptional regulators with an established role in embryonic development. The HoxA10 gene is related to the Abdominal B (AbdB) homeobox subfamily of genes and is expressed in both the developing genitourinary tract and in the adult uterus. HoxA10 expression increases during the midsecretory phase of the menstrual cycle, which corresponds with increased levels of circulating progesterone, as evidenced by Northern blot analysis. Furthermore, HoxA10 expression in-creases in a concentration-dependent manner with progesterone stimulation in cultured endometrial cells and is blocked by the progesterone receptor antagonist RU486. In addition, HoxA10 is differentially expressed in the myometrium throughout the menstrual cycle, both in vivo and in vitro, with decreased expression coinciding with increased progesterone levels. In contrast with a control group, female patients with documented endometriosis do not exhibit a mid-luteal increase in uterine Hox gene expression, which may contribute to the pathology of the disease.
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Informations pour la commande
Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps HoxA10 (F-4) | sc-271954 | 200 µg/ml | $316.00 | |||
HoxA10 (F-4): m-IgGκ BP-HRP Kit | sc-535071 | 200 µg Ab; 40 µg BP | $354.00 | |||
HoxA10 (F-4): m-IgG2b BP-HRP Kit | sc-549340 | 200 µg Ab; 10 µg BP | $354.00 | |||
HoxA10 (F-4) peptide neutralisant | sc-271954 P | 100 µg/0.5 ml | $68.00 | |||
Anticorps HoxA10 (F-4) X | sc-271954 X | 200 µg/0.1 ml | $316.00 |