Microtubules mediate the spatial organization of diverse membrane-trafficking systems. The HOOK proteins, HOOK1, HOOK2 and HOOK3, comprise a family of cytosolic coiled-coil proteins that contain conserved N-terminal domains, which attach to microtubules; and more divergent C-terminal domains, which mediate binding to organelles. HOOK2 (also known as HK2) is 719 amino acids in length. It exists as a homodimer, most likely mediated through its central coiled-coil domain. HOOK2 may associate with SURF1 and Zic2, and all three may be potential esophageal cancer tumor antigens. HOOK2 expression is strong in the larynx and the esophagus. Unlike HOOK3, which localizes to the Golgi, HOOK2 localizes to discrete subcellular structures not corresponding to early or late endosomes, mitochondria, Golgi complex, endoplasmic reticulum, lysosomes or multivesicular bodies.
Informations pour la commande
Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps HOOK2 (E-4) | sc-137107 | 200 µg/ml | $316.00 |