Homer-3 Antibody (H-5): sc-271653
- Homer-3 Antibody (H-5) is a mouse monoclonal IgG2a κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 337-360 at the C-terminus of Homer-3 of human origin
- recommended for detection of Homer-3a and Homer-3b of mouse, rat and human origin by WB, IP, IF and ELISA
- See Homer (D-3): sc-17842 for Homer-3 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP, m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Homer-3 Antibody (H-5) for WB applications. These reagents are now offered in bundles with Homer-3 Antibody (H-5) (see ordering information below).
Homer-3 Antibody (H-5) is a mouse monoclonal IgG2a antibody that detects Homer-3 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Homer-3 is a member of the Homer family of proteins, which are crucial for synaptic signaling and plasticity, particularly in the context of group 1 metabotropic glutamate receptors (mGluRs). Homer-3 plays a significant role in linking mGluRs to intracellular signaling pathways, including the inositol triphosphate receptors, which are essential for calcium release within cells. Homer-3′s ability to form multimeric complexes through its coiled-coil domain enhances its function in stabilizing receptor interactions and modulating synaptic responses. Understanding the dynamics of Homer-3 and its interactions is vital for elucidating the mechanisms underlying synaptic plasticity and the potential implications in neurological disorders. Anti-Homer-3 antibody (H-5) is an invaluable tool for researchers investigating these critical pathways in various biological contexts.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Homer-3 Antibody (H-5) References:
- Homer2 and Homer3 interact with amyloid precursor protein and inhibit Abeta production. | Parisiadou, L., et al. 2008. Neurobiol Dis. 30: 353-364. PMID: 18387811
- A new mechanism in the binding between Homer3 EVH1 domain and inositol 1,4,5 trisphosphate receptor suppressor domain. | Wen, H., et al. 2014. Biochem Cell Biol. 92: 163-71. PMID: 24901889
- Anti-Homer-3 antibody associated cerebellar ataxia: A rare case report and literature review. | Xu, X., et al. 2019. J Neuroimmunol. 330: 155-158. PMID: 30904736
- [Effect of mammalian target of rapamycin on cognitive dysfunction of Alzheimer's Disease via regulating Homer3]. | Huang, YQ., et al. 2020. Zhonghua Yi Xue Za Zhi. 100: 1336-1340. PMID: 32375443
- Neurological Autoimmunity Associated With Homer-3 Antibody: A Case Series From China. | Liu, M., et al. 2021. Neurol Neuroimmunol Neuroinflamm. 8: PMID: 34580182
- Homer-3 Antibody Disease: A Potentially Treatable MSA-C Mimic. | Mulroy, E., et al. 2022. Mov Disord Clin Pract. 9: 178-182. PMID: 35146057
- Cerebellar Swelling Followed by Atrophy in Anti-Homer-3 Antibody-Associated Cerebellitis. | Hu, Y. and Sun, Q. 2022. Neurology. 99: 610-611. PMID: 35858816
- HOMER-3 Antibodies Were Not Detected in Two German Cohorts of Patients with Multiple System Atrophy. | Klietz, M., et al. 2022. Mov Disord. 37: 2165-2166. PMID: 35975882
- Corrigendum: Case report and literature analysis: Autoimmune cerebellar ataxia associated with homer-3 antibodies. | Wu, Q., et al. 2023. Front Neurol. 14: 1187907. PMID: 37056361
- HOMER3 promotes non-small cell lung cancer growth and metastasis primarily through GABPB1-mediated mitochondrial metabolism. | Sun, T., et al. 2023. Cell Death Dis. 14: 814. PMID: 38081871
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Homer-3 Antibody (H-5) | sc-271653 | 200 µg/ml | $322.00 | |||
Homer-3 Antibody (H-5): m-IgG Fc BP-HRP Bundle | sc-537674 | 200 µg Ab; 10 µg BP | $361.00 | |||
Homer-3 Antibody (H-5): m-IgGκ BP-HRP Bundle | sc-535015 | 200 µg Ab; 40 µg BP | $361.00 | |||
Homer-3 Antibody (H-5): m-IgG2a BP-HRP Bundle | sc-548082 | 200 µg Ab; 10 µg BP | $361.00 | |||
Homer-3 (H-5) Neutralizing Peptide | sc-271653 P | 100 µg/0.5 ml | $69.00 |