Homer family proteins, also designated Vesl (for VASP/Ena-related gene upregulated during seizure) and LTP, are immediate early gene products that bind to group 1 metabotropic glutamate receptors (mGluRs), proteins involved in triggering intracellular calcium release. Unlike Homer-1a, the prototype member of the Homer family, other Homer family members (Homer-1b and -1c, Homer-2a, -2b and -2c and Homer-3) are constitutively expressed and contain a coiled-coil (CC) domain that mediates self-multimerization. Homer-1a is enriched at excitatory synapses, does not multimerize and appears to block the association of mGluRs to CC-Homer proteins. Homer proteins have also been shown to link mGluRs with the inositol triphosphate receptors (IP3R).
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Informations pour la commande
Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps Homer-3 (E-6) | sc-376155 | 200 µg/ml | $316.00 | |||
Homer-3 (E-6): m-IgGκ BP-HRP Kit | sc-550752 | 200 µg Ab; 40 µg BP | $354.00 |