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Histone H10 (H1 histone family, member 0) is a lysine-rich member of the H1 family of linker histones. The H1 family of proteins interacts with linker DNA between nucleosomes and mediates compaction into higher order chromatin. Histone H10 is a unique variant, considered a replacement linker histone, which is expressed and incorporated into chromatin in the absence of DNA replication. In contrast, the majority of somatic H1 histones are replication dependent variants found in proliferating cells. Histone H10 is expressed in cells that are in the terminal stages of differentiation or that have low rates of cell division. Unlike other differentiation-specific linker histones which demonstrate tissue and species-specific expression, Histone H10 is widely expressed in many tissues in most vertebrates. Histone H10 is derived from an intronless gene, H1F0, which has been mapped to human chromosome 22q13.1. Histones are subject to posttranslational modification by enzymes, primarily on their N-terminal tails, but also in their globular domains. Such modifications include methylation, citrullination, acetylation, phosphorylation, sumoylation, ubiquitination and ADP-ribosylation.
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Informations pour la commande
Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps Histone H10 (27) | sc-56694 | 200 µg/ml | $316.00 | |||
Histone H10 (27): m-IgG Fc BP-HRP Kit | sc-537115 | 200 µg Ab; 10 µg BP | $354.00 | |||
Histone H10 (27): m-IgGκ BP-HRP Kit | sc-534307 | 200 µg Ab; 40 µg BP | $354.00 | |||
Histone H10 (27): m-IgG1 BP-HRP Kit | sc-545013 | 200 µg Ab; 20 µg BP | $354.00 |