HIP1 Antibody (1B11): sc-47755

HIP1 Antibody (1B11) is a mouse monoclonal IgG1 antibody that detects HIP1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). HIP1, or huntingtin-interacting protein 1, plays a critical role in maintaining cellular integrity, particularly in the brain, where HIP1 is ubiquitously expressed at low levels across various regions. HIP1 is essential for vesicle trafficking, as HIP1 contains a C-terminal actin-binding domain, a central coiled-coil region, and an N-terminal ENTH domain, which together facilitate interaction with the cytoskeleton and membrane structures. The structural integrity of HIP1 is vital for the maintenance of normal vesicle size in vivo, and any disruption in HIP1 function can lead to compromised membrane-cytoskeletal integrity, particularly in the context of Huntington′s disease, where the interaction between HIP1 and huntingtin is inversely correlated with the length of the polyglutamine tract in huntingtin. Anti-HIP1 antibody (1B11) is an invaluable tool for researchers studying the dynamics of vesicle trafficking and the molecular mechanisms underlying neurodegenerative diseases, providing insights into the critical interactions that sustain neuronal health.

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HIP1 Antibody (1B11) References:

1. The huntingtin interacting protein HIP1 is a clathrin and alpha-adaptin-binding protein involved in receptor-mediated endocytosis.  |  Waelter, S., et al. 2001. Hum Mol Genet. 10: 1807-17. PMID: 11532990
2. Huntingtin interacting protein 1 Is a clathrin coat binding protein required for differentiation of late spermatogenic progenitors.  |  Rao, DS., et al. 2001. Mol Cell Biol. 21: 7796-806. PMID: 11604514
3. Huntingtin-interacting protein 1 is overexpressed in prostate and colon cancer and is critical for cellular survival.  |  Rao, DS., et al. 2002. J Clin Invest. 110: 351-60. PMID: 12163454
4. Huntingtin interacting protein 1 (HIP1) regulates clathrin assembly through direct binding to the regulatory region of the clathrin light chain.  |  Legendre-Guillemin, V., et al. 2005. J Biol Chem. 280: 6101-8. PMID: 15533941
5. Huntingtin interacting protein 1 is a novel brain tumor marker that associates with epidermal growth factor receptor.  |  Bradley, SV., et al. 2007. Cancer Res. 67: 3609-15. PMID: 17440072
6. Actin binding by Hip1 (huntingtin-interacting protein 1) and Hip1R (Hip1-related protein) is regulated by clathrin light chain.  |  Wilbur, JD., et al. 2008. J Biol Chem. 283: 32870-9. PMID: 18790740
7. Huntingtin-interacting protein 1: a Merkel cell carcinoma marker that interacts with c-Kit.  |  Ames, HM., et al. 2011. J Invest Dermatol. 131: 2113-20. PMID: 21697888
8. Huntingtin-interacting protein 1 phosphorylation by receptor tyrosine kinases.  |  Ames, HM., et al. 2013. Mol Cell Biol. 33: 3580-93. PMID: 23836884
9. Huntingtin-Interacting Protein-1 Is an Early-Stage Prognostic Biomarker of Lung Adenocarcinoma and Suppresses Metastasis via Akt-mediated Epithelial-Mesenchymal Transition.  |  Hsu, CY., et al. 2016. Am J Respir Crit Care Med. 193: 869-80. PMID: 26595459
10. Fusion of Huntingtin interacting protein 1 to platelet-derived growth factor beta receptor (PDGFbetaR) in chronic myelomonocytic leukemia with t(5;7)(q33;q11.2).  |  Ross, TS., et al. 1998. Blood. 91: 4419-26. PMID: 9616134

The preferred HIP1 antibody is HIP1 Antibody (4B10): sc-47754.