Anticorps hCAP-G (YY-2): sc-101014

hCAP-G (condensin complex subunit 3, condensin subunit CAP-G) is a 1,015 amino acid protein that is encoded by the human gene NCAPG. hCAP-G belongs to the CND3 (condensin subunit 3) family and contains ten HEAT repeats. hCAP-G is a regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. In interphase cells, the majority of the condensin complex is found in the cytoplasm, while a minority of the complex is associated with chromatin. A subpopulation of the complex, however, remains associated with chromosome foci in interphase cells. During mitosis, most of the condensin complex is associated with the chromatin. At the onset of prophase, the regulatory subunits of the complex are phosphorylated by CDC2, leading to association of condensin with chromosome arms and to chromosome condensation. Dissociation from chromosomes is observed in late telophase.

L'anticorps hCAP-G préféré est l'Anticorps hCAP-G (B-1): sc-515297.