CD44 Antibody (OX50): sc-53069

HCAM Antibody (OX50) is a mouse monoclonal IgG1 antibody that detects HCAM in mouse and rat samples through applications such as immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and flow cytometry (FCM). HCAM, also known as CD44, is a 742 amino acid single-pass type I membrane protein that plays a crucial role in cell adhesion and migration, which are vital processes in embryogenesis, immune response, and tumor metastasis. HCAM functions as a receptor for hyaluronic acid (HA) and interacts with various ligands, including osteopontin (OPN), facilitating both cell-cell and cell-matrix interactions. HCAM′s structure features a Link domain and multiple isoforms generated through alternative splicing, such as CD44R, CDw44, CD44S, CD44H, and CD44E. The CD44H isoform shows high expression in cancer tissues, indicating its potential role in tumor progression and making HCAM a critical target for cancer research. Anti-HCAM antibody (OX50) serves as an essential tool for researchers investigating the dynamics of cell adhesion and migration in various biological contexts, particularly in the study of cancer biology and immune responses.

The preferred CD44 antibody is CD44 Antibody (DF1485): sc-7297.