CD44 Antibody (OX49): sc-53068

HCAM Antibody (OX49) is a mouse monoclonal IgG2a antibody that detects HCAM in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and flow cytometry (FCM). HCAM, also known as CD44, is a 742 amino acid single-pass type I membrane protein that plays a crucial role in cell adhesion and migration, which are vital processes in embryogenesis, immune response, and tumor metastasis. HCAM functions as a receptor for hyaluronic acid (HA) and interacts with ligands such as osteopontin (OPN), facilitating both cell-cell and cell-matrix interactions. HCAM′s structure features a Link domain, which is essential for binding capabilities, and undergoes alternative splicing, resulting in multiple isoforms such as CD44R, CDw44, CD44S, CD44H, and CD44E. The CD44H isoform is highly expressed in cancer tissues, indicating a potential role in tumor progression and making anti-HCAM antibody (OX49) a critical tool for cancer research. With broad reactivity and versatile applications, HCAM (OX49) monoclonal antibody serves as an invaluable resource for researchers studying cell adhesion mechanisms and their implications in health and disease.

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CD44 Antibody (OX49) References:

1. Fluticasone and salmeterol downregulate in vitro, fibroblast proliferation and ICAM-1 or H-CAM expression.  |  Silvestri, M., et al. 2001. Eur Respir J. 18: 139-45. PMID: 11510784
2. The adhesion molecules NCAM, HCAM, PECAM-1 and ICAM-1 in normal salivary gland tissues and salivary gland malignancies.  |  Perschbacher, K., et al. 2004. J Oral Pathol Med. 33: 230-6. PMID: 15061711
3. H-CAM expression in the human nervous system: evidence for a role in diverse glial interactions.  |  Vogel, H., et al. 1992. J Neurocytol. 21: 363-73. PMID: 1607880
4. The hyaluronate receptor is a member of the CD44 (H-CAM) family of cell surface glycoproteins.  |  Culty, M., et al. 1990. J Cell Biol. 111: 2765-74. PMID: 1703543
5. Expression of beta 1-integrins, H-CAM (CD44) and LECAM-1 in primary gastro-intestinal B-cell lymphomas as compared to the adhesion receptor profile of the gut-associated lymphoid system, tonsil and peripheral lymph node.  |  Möller, P., et al. 1991. Int J Cancer. 49: 846-55. PMID: 1720425
6. Development of the fluorescent biosensor hCalmodulin (hCaM)L39C-monobromobimane(mBBr)/V91C-mBBr, a novel tool for discovering new calmodulin inhibitors and detecting calcium.  |  Gonzalez-Andrade, M., et al. 2011. J Med Chem. 54: 3875-84. PMID: 21495717
7. Molecular cloning and expression of Pgp-1. The mouse homolog of the human H-CAM (Hermes) lymphocyte homing receptor.  |  Zhou, DF., et al. 1989. J Immunol. 143: 3390-5. PMID: 2681416
8. Flow cytometric detection of CD44 (H-CAM) in hairy cell leukemia.  |  Rutella, S., et al. 1996. Leuk Lymphoma. 21: 497-500. PMID: 9172816
9. Expression of CD44 (HCAM) in small lymphocytic and mantle cell lymphoma.  |  Aguilera, NS., et al. 1998. Hum Pathol. 29: 1134-9. PMID: 9781654
10. CD44 (H-CAM) is differently expressed on circulating and bone marrow hairy cells.  |  Rutella, S., et al. 1997. Eur J Histochem. 41 Suppl 2: 49-50. PMID: 9859779

The preferred CD44 antibody is CD44 Antibody (DF1485): sc-7297.