CD44 Antibody (BU52): sc-65265
- CD44 Antibody (BU52) is a mouse monoclonal IgG1 κ, cited in 7 publications, provided at 200 µg/ml
- raised against peripheral myeloma cells of human origin
- recommended for detection of HCAM of human origin by WB, IP, IF and FCM
- available conjugated to either phycoerythrin or FITC for IF, IHC(P) and FCM
- See CD44 (DF1485): sc-7297 for CD44 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for CD44 Antibody (BU52) for WB applications. These reagents are now offered in bundles with CD44 Antibody (BU52) (see ordering information below).
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HCAM Antibody (BU52) is a mouse monoclonal IgG1 antibody that detects HCAM in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). HCAM, also known as CD44, is a 742 amino acid single-pass type I membrane protein that plays a crucial role in cell adhesion and migration, which are vital processes in embryogenesis, immune response, and tumor metastasis. This protein functions primarily as a receptor for hyaluronic acid (HA) and interacts with various ligands, including osteopontin (OPN), facilitating both cell-cell and cell-matrix interactions. HCAM′s structure features a Link domain, which is essential for binding capabilities and functional versatility. HCAM undergoes alternative splicing, resulting in multiple isoforms such as CD44R, CDw44, CD44S, CD44H, and CD44E, with CD44H being particularly prominent in cancer tissues. High expression levels in tumors suggest HCAM, especially CD44H variant, may play a pivotal role in tumor progression and metastasis, making HCAM a critical target for cancer research and therapeutic interventions. Anti-HCAM antibody (BU52) serves as an invaluable tool for researchers investigating cell adhesion and migration in various biological contexts.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
CD44 Antibody (BU52) References:
- CD44 expression in tuberous sclerosis. | Arai, Y., et al. 2000. Pathobiology. 68: 87-92. PMID: 10878505
- Induction of CD44 cleavage in articular chondrocytes. | Takahashi, N., et al. 2010. Arthritis Rheum. 62: 1338-48. PMID: 20178130
- CD44 regulates pancreatic cancer invasion through MT1-MMP. | Jiang, W., et al. 2015. Mol Cancer Res. 13: 9-15. PMID: 25566991
- Expression of CD44 in pancreatic cancer and its significance. | Li, XP., et al. 2015. Int J Clin Exp Pathol. 8: 6724-31. PMID: 26261555
- MiR-492 regulates metastatic properties of hepatoblastoma via CD44. | von Frowein, J., et al. 2018. Liver Int. 38: 1280-1291. PMID: 29314711
- Impact of structurally modifying hyaluronic acid on CD44 interaction. | Bhattacharya, D., et al. 2017. J Mater Chem B. 5: 8183-8192. PMID: 29354263
- Extravillous trophoblast invasion accelerated by WNT3A, 5A, and 10B via CD44. | Takahashi, H., et al. 2021. J Matern Fetal Neonatal Med. 34: 3377-3385. PMID: 31736372
- Still proliferating CD44+/Ki67+ tumor cells after neoadjuvant radiochemotherapy identify rectal cancer patients with poor survival. | Klose, J., et al. 2021. Eur J Surg Oncol. 47: 2078-2086. PMID: 33814238
- Cytotoxicity of curcumin against CD44± prostate cancer cells: Roles of miR-383 and miR-708. | Panahizadeh, R., et al. 2023. Avicenna J Phytomed. 13: 429-441. PMID: 37663388
- CD44 occupancy prevents macrophage multinucleation. | Sterling, H., et al. 1998. J Cell Biol. 143: 837-47. PMID: 9813101
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CD44 Antibody (BU52) | sc-65265 | 200 µg/ml | $322.00 | |||
CD44 Antibody (BU52): m-IgG Fc BP-HRP Bundle | sc-539166 | 200 µg Ab; 10 µg BP | $361.00 | |||
CD44 Antibody (BU52): m-IgG1 BP-HRP Bundle | sc-541306 | 200 µg Ab; 20 µg BP | $361.00 | |||
CD44 Antibody (BU52) FITC | sc-65265 FITC | 200 µg/ml | $336.00 | |||
CD44 Antibody (BU52) PE | sc-65265 PE | 200 µg/ml | $349.00 |