Anticorps Hantavirus NC (HN-1): sc-65928

Hantaviruses are members of the bunyaviridae family of viruses that have a negative-sensed, single-stranded RNA genome that consists of three single-stranded RNA segments designated small (S), medium (M), and large (L). These genes encode the nucleocapsid protein, a polyprotein that is co-translationally cleaved to yield the envelope glycoproteins G1 and G2, and the L protein, which functions as the viral transcriptase/replicase. Transcription of the Hantavirus genes is initiated by association of the L protein with the three nucleocapsid (NC) species. The G1 and G2 glycoproteins form hetero-oligomers that are then transported from the endoplasmic reticulum to the Golgi complex, where glycosylation is completed. Hantavirus virions most likely assemble by association of NCs with glycoproteins embedded in the membranes of the Golgi. Hantavirus causes Hemorrhagic Fever with Renal Syndrome (HFRS) as well as Hantavirus (Cardio-)Pulmonary Syndrome (HPS or HCPS).