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GRP1 (general receptor for phosphoinositides-1) contains a pleckstrin homology (PH) domain as well as a Sec7 domain. The PH domain has high binding affinity for phosphatidylinositol 3,4,5-trisphosphate (Ptdlns(3,4,5)P3), while the Sec7 homology domain is responsible for catalyzing guanine nucleotide exchange of ADP-ribosylation factor (ARF) proteins. GRP1 co-localizes with ARF6 and catalyzes GTP/GDP exchange on ARF6. It is known to interact with Ptdlns(3,4,5)P3 localized to the plasma membrane in vitro and may also be a Ptdlns(3,4,5)P3 receptor. Additionally, GRP1 may regulate protein sorting and membrane trafficking through interaction with the guanosine triphosphate ARF, and may control cell adhesion through interaction with integrins.
Informations pour la commande
Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps GRP1 (A-10) | sc-374437 | 200 µg/ml | $316.00 | |||
GRP1 (A-10): m-IgG Fc BP-HRP Kit | sc-540453 | 200 µg Ab; 10 µg BP | $354.00 | |||
GRP1 (A-10): m-IgG1 BP-HRP Kit | sc-542133 | 200 µg Ab; 20 µg BP | $354.00 | |||
GRP1 (A-10) peptide neutralisant | sc-374437 P | 100 µg/0.5 ml | $68.00 |