Anticorps GRF-1 (D-11): sc-390998
- L'Anticorps GRF-1 (D-11) est un monoclonal de souris IgG2a (chaîne légère kappa) fourni en 200 µg/ml
- dirigé contre les acides aminés 881-1080 dans une région interne de GRF-1 d'origine human
- recommandé pour la détection de GRF-1 isoforms 1 and 2 d'origine mouse, rat et human par WB, IP, IF et ELISA
- Le m-IgG Fc BP-HRP est le réactif de détection secondaire préféré pour l'anticorps GRF-1 (D-11) pour les applications WB. Ce réactif est désormais proposé en bundle avec l'anticorps GRF-1 (D-11)(voir les informations de commande ci-dessous).
ACCÈS RAPIDE AUX LIENS
VOIR ÉGALEMENT...
The glucocorticoid receptor (GR) is a ligand-dependent, transactivating regulatory protein that is a member of the nuclear receptor superfamily. GRF-1 (glucocorticoid receptor DNA-binding factor 1), also known as p190RhoGAP or simply p190, is a transcriptional regulator which binds to the promoter region of the glucocorticoid receptor gene and represses its expression. By repressing GR expression, GRF-1 acts to down-regulate Rho signaling, thereby mediating both actin cytoskeletal rearrangements and cell cycle events. Through its GAP domain, GRF-1 is thought to affect cytokinesis by regulating Rho activity; a regulation that is controlled by the ubiquination of the GTP binding region and subsequent degradation of GRF-1. Additionally, GRF-1 plays an important role in oligodendrocyte differentiation, a process that is absent in malignant glioma tumors, implicating GRF-1 as a possible tumor suppressor. GRF-1 expression is regulated by glucocorticoids and the expressed protein exists as two isoforms produced by alternative splicing events.
Informations pour la commande
| Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps GRF-1 (D-11) | sc-390998 | 200 µg/ml | $316.00 | |||
GRF-1 (D-11): m-IgG Fc BP-HRP Kit | sc-540882 | 200 µg Ab; 10 µg BP | $354.00 |