Anticorps Glutathione Peroxidase 1/2/GPX1/2 (D-12): sc-133152
- L'Anticorps Glutathione Peroxidase 1/2/GPX1/2 (D-12) est un monoclonal de souris IgG1 κ, cité dans 19 publications, fourni en 200 µg/ml
- soulevée contre les acides aminés 50-201 correspondant à C-terminus de GPx-1 d'origine human.
- recommandé pour la détection de GPx-1 and GPx-2 d'origine mouse, rat et human par WB, IP, IF, IHC(P) et ELISA
- Voir Glutathione Peroxidase 1/2/GPX1/2 (B-6): sc-133160 pour d'autres anticorps conjugués Glutathione Peroxidase 1/2/GPX1/2, dont AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 et 790.
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP et m-IgGκ BP-HRP sont les réactifs secondaires recommandés pour la détection de l'anticorps Glutathione Peroxidase 1/2/GPX1/2 (D-12) pour des applications de WB and IHC(P). Ces réactifs sont maintenant proposés en kit avec l'anticorps Glutathione Peroxidase 1/2/GPX1/2 (D-12) (voir Informations pour la commande ci-dessous).
Glutathione peroxidase (GPx) enzymes are generally selenium-containing tetrameric glycoproteins that help prevent lipid peroxidation of cell membranes. GPx enzymes reduce lipid hydroperoxides to alcohols, and reduce free hydrogen peroxide to water. GPx members are among the few proteins known in higher vertebrates to contain selenocysteine, which occurs at the active site of glutathione peroxidase and is coded by the nonsense (stop) codon TGA. There are eight GPx homologs (GPx-1-8). GPx-1, Gpx-2 and Gpx-3 exist as homotetramers. Gpx-4 has a high tendancy to form high molecular weight oligomers. GPx-1 plays an important role in the antioxidant defense of the vascular wall and neural cells in response to oxidative stress. GPx-2 is the major isoform in the lungs and its basal or inducible expression is dependent on Nrf2. GPx-3 is under regulation by hypoxic stress and the expression and deficiency of GPx-3 is associated with cardiovascular disease and stroke. GPx-5 is selenium-independent; it is bound to the acrosome of sperm, where it may protect sperm from premature acrosome reaction in the epididymis.
Informations pour la commande
| Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps Glutathione Peroxidase 1/2/GPX1/2 (D-12) | sc-133152 | 200 µg/ml | $316.00 | |||
Glutathione Peroxidase 1/2/GPX1/2 (D-12): m-IgG Fc BP-HRP Kit | sc-537345 | 200 µg Ab; 10 µg BP | $354.00 | |||
Glutathione Peroxidase 1/2/GPX1/2 (D-12): m-IgGκ BP-HRP Kit | sc-534588 | 200 µg Ab; 40 µg BP | $354.00 | |||
Glutathione Peroxidase 1/2/GPX1/2 (D-12): m-IgG1 BP-HRP Kit | sc-545147 | 200 µg Ab; 20 µg BP | $354.00 |