Anticorps Gemin2 (A-9): sc-166187
- L'Anticorps Gemin2 (A-9) est un monoclonal de souris IgG2b κ, cité dans 2 publications, fourni en 200 µg/ml
- soulevée à l'encontre des acides aminés 2-101 correspondant à N-terminus de Gemin2 d'origine human.
- recommandé pour la détection de Gemin2 d'origine mouse, rat et human par WB, IP, IF et ELISA
- m-IgG Fc BP-HRP, 2b BP-HRP">m-IgG2b BP-HRP et m-IgGκ BP-HRP sont les réactifs de détection secondaire préférés pour l'anticorps Gemin2 (A-9) pour les applications WB. Ces réactifs sont désormais proposés en lots avec l'anticorps Gemin2 (A-9)(voir les informations de commande ci-dessous).
Spinal muscular atrophy (SMA) is an autosomal recessive neurodegenerative disease characterized by loss of motor neurons in the spinal cord. SMA is caused by deletion or loss-of-function mutations in the SMN (survival of motor neuron) gene. Gemin2 (formerly known as SIP1 for SMN interacting protein) associates directly with SMN and is a part of the SMN complex containing Gemin3 (a DEAD-box RNA helicase), Gemin4, Gemin5 and Gemin6, as well as several spliceosomal snRNP proteins. The SMN complex plays an essential role in splicesomal snRNP assembly in the cytoplasm and is required for pre-mRNA splicing of the nucleus. It is found in both the cytoplasm and the nucleus. The nuclear form is concentrated in subnuclear bodies called gems (Gemini of the coiled bodies). The SMN-Gemin2 complex is associated with spliceosomal snRNAs U1 and U5. Gemin2 is expressed in spinal cord. It can be induced by TGFβ treatment and expression is high in several E-cadherin negative human carcinoma cell lines. SMN is expressed in a wide variety of tissues including brain, kidney, liver and spinal cord, and moderately in skeletal and cardiac muscle.
Informations pour la commande
| Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps Gemin2 (A-9) | sc-166187 | 200 µg/ml | $316.00 | |||
Gemin2 (A-9): m-IgG Fc BP-HRP Kit | sc-537453 | 200 µg Ab; 10 µg BP | $354.00 | |||
Gemin2 (A-9): m-IgGκ BP-HRP Kit | sc-534725 | 200 µg Ab; 40 µg BP | $354.00 | |||
Gemin2 (A-9): m-IgG2b BP-HRP Kit | sc-549874 | 200 µg Ab; 10 µg BP | $354.00 |