ACCÈS RAPIDE AUX LIENS
The intracellular stimulation of guanylate cyclase (GC) by calcium, a key event in the recovery of the dark state of rod photoreceptors after exposure to light, is mediated by guanylate cyclase-activating protein (GCAP1). GCAPs are calcium-binding proteins belonging to the calmodulin superfamily. GCAP1 is a calcium-binding protein that stimulates synthesis of c-GMP in photoreceptors. GCAP1 is present in rod and cone photoreceptor outer segments where phototransduction occurs. In contrast to other calcium-binding proteins from the calmodulin superfamily, the calcium-free form of GCAP1 stimulates the effector enzyme. By molecular cloning of human and mouse GCAP cDNA, the known mammalian GCAPs are found to be more than 90% similar, consisting of 201 to 205 amino acids, and containing three identically conserved calcium-binding sites. A related protein, GCAP2, is detectable only in the retina and results from a gene duplication event.
Informations pour la commande
Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps GCAP1 (F-6) | sc-390678 | 200 µg/ml | $316.00 | |||
GCAP1 (F-6): m-IgG Fc BP-HRP Kit | sc-540833 | 200 µg Ab; 10 µg BP | $354.00 | |||
GCAP1 (F-6): m-IgG2a BP-HRP Kit | sc-546965 | 200 µg Ab; 10 µg BP | $354.00 |