Garcinol CAS: 78824-30-3
MF: C38H50O6
MW: 602.80
A potent p300 and PCAF histone acetyltransferase inhibitor.

Garcinol (CAS 78824-30-3)

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 102ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
5
1
4
0
3
0
2
0
1
0
Synonyme: Camboginol
Application: A potent p300 and PCAF histone acetyltransferase inhibitor
Numéro CAS: 78824-30-3
Pureté: ≥95%
Masse Moléculaire: 602.80
Formule Moléculaire: C38H50O6
* Consulter le Certificat d'Analyses pour les données spécifiques à un lot (incluant la teneur en eau).
Postez un avis sur ce produit et recevez 15 CruzCredits

Garcinol (camboginol) is a polyisoprenylated benzophenone derivative from the rind of Garcinia indica fruit and is a potent inhibitor of histone acetyltransferases p300 (IC50 ~ 7 μM) and PCAF (IC50 ~ 5 μM) in vitro. P300, also known as E1A binding protein p300, regulates cell growth and division via interactions with numerous transcription factors, and the p53 associated trancriptional coactivator PCAF (P300/CBP-associated factor) plays a direct role in transcriptional regulation. Reports show that garcinol represses the p300-mediated acetylation of p53 and promotes apoptosis through caspase-3 activation. Additionally, this compound predominantly down-regulates global gene expression in HeLa cells. Researchers found that garcinol exhibits dose-dependent cancer cell-specific growth inhibition in ER-positive MCF-7 and ER-negative MDA-MB-231 breast cancer cells. Additional research shows that garcinol exhibits anti-carcinogenic and antiiinflammatory properties through selective suppression of prostaglandin E2 synthesis and 5-lipoxygenase product formation.


Références

1. Matsumoto, Kenji., et al., 2003. Cytotoxic benzophenone derivatives from Garcinia species display a strong apoptosis-inducing effect against human leukemia cell lines. Biological & pharmaceutical bulletin. 26(4): 569-71. PMID: 12673047
2. Balasubramanyam, Karanam., et al., 2004. Polyisoprenylated benzophenone, garcinol, a natural histone acetyltransferase inhibitor, represses chromatin transcription and alters global gene expression. The Journal of biological chemistry. 279(32): 33716-26. PMID: 15155757
3. Mantelingu, K., et al., 2007. Specific inhibition of p300-HAT alters global gene expression and represses HIV replication. Chemistry & biology. 14(6): 645-57. PMID: 17584612
4. Koeberle, Andreas., et al., 2009. Identification of 5-lipoxygenase and microsomal prostaglandin E2 synthase-1 as functional targets of the anti-inflammatory and anti-carcinogenic garcinol. Biochemical pharmacology. 77(9): 1513-21. PMID: 19426689
5. Ahmad, Aamir., et al., 2010. Apoptosis-inducing effect of garcinol is mediated by NF-kappaB signaling in breast cancer cells. Journal of cellular biochemistry. 109(6): 1134-41. PMID: 20108249
6. Chen, Ching-Shyang., et al., 2011. Nicotine-induced human breast cancer cell proliferation attenuated by garcinol through down-regulation of the nicotinic receptor and cyclin D3 proteins. Breast cancer research and treatment. 125(1): 73-87. PMID: 20229177

État Physique :
Solid
Solubilité :
Soluble in ethanol (25 mg/ml), DMSO (25 mg/ml), and DMF (25 mg/ml). Insoluble in water.
STOCKAGE :
Store at -20° C
Point de fusion :
72° C
Point d'Ébullition :
~710.8° C at 760 mmHg (Predicted)
Densité :
~1.1 g/cm3 (Predicted)
Indice de Réfraction :
n20D 1.56
IC50 :
histone acetyltransferases (HATs) p300: IC50 = 7 µM; PCAF: IC50 = 5 µM
Ki Data :
Histone acetyltransferase p300: Ki= 4900 nM
Valeurs pK :
pKa: 4.5
Pour la Recherche Uniquement. Non conforme pour le Diagnostic ou pour une Utilisation Thérapeutique.
WGK Allemagne :
2
PubChem CID :
3531
Numéro MDL :
MFCD03700761
SMILES :
CC(=CCC1CC2(C(=O)C(=C(C3=CC(=C(C=C3)O)O)O)C(=O)C(C2=O)(C1(C)C)CC=C(C)C)CC(CC=C(C)C)C(=C)C)C

Télécharger la Fiche de Sécurité/ SDS (MSDS)

CERTIFICAT D'ANALYSE

Pour une bonne lecture, Adobe Acrobat Reader est requis,
imprimer et commenter les documents PDF

Garcinol  Références bibliographiques

Consultez les publications faisant référence à l' utilisation de Garcinol. Cliquez sur le lien pour afficher lentrée PubMed .

Citations 1 à 6 sur un total de 6

PMID: # 29174768  Ghosh, TK. et al. 2018. J. Mol. Cell. Cardiol. 114: 185-198.

PMID: # 29414668  Huang, WC.|Kuo, KT.|Adebayo, BO.|Wang, CH.|Chen, YJ.|Jin, K.|Tsai, TH.|Yeh, CT.| et al. 2018. J. Nutr. Biochem. 54: 140-150.

PMID: # 29740418  Simpson, S. et al. 2018. Front Microbiol. 9: 788.

PMID: # 25538147  Yao, XH. et al. 2014. Physiological reports. 2:

PMID: # 23644046  Du, T. et al. 2013. Experimental and molecular pathology. 95: 38-45.

PMID: # 30377593  Habibi, A.|Soleimani, M.|Atashi, A.|AkhavanRahnama, M.|Anbarlou, A.|Ajami, M.|Ajami, M.| et al. Avicenna J Phytomed. 8: 350-357.

Citations 1 à 6 sur un total de 6
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 114ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 10ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;

Santa Cruz Biotechnology, Inc. est leader mondial dans le développement de produits pour la recherche biomédicale. Contactez-nous au 1-800-457-3801.
Copyright © 2007-2020 Santa Cruz Biotechnology, Inc. Tous Droits Réservés. "Santa Cruz Biotechnology", et le logo Santa Cruz Biotechnology, Inc., "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", le logo San Juan Ranch, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", et "EZ Touch" sont des marques déposées de Santa Cruz Biotechnology, Inc.
Toutes les marques sont la propriété de leurs propriétaires respectifs.