Molecular structure of FPT Inhibitor II
FPT Inhibitor II
See product citations (1)
Application:
FPT Inhibitor II is a potent Farnesyl Transferase and Ras farnesylation inhibitor
Molecular Weight:
403.36
Molecular Formula:
C17H28NO5P•2Na
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
FPT Inhibitor II is a cell permeable, potent and selective inhibitor of Farnesyl Transferase. Is resistant to cleavage by phosphorylation. FPT Inhibitor II and has also exhibited inhibitory effects of Ras farnesylation in whole cells.
FPT Inhibitor II References
- Advanced glycosylation end products induce nitric oxide synthase expression in C6 glioma cells: involvement of a p38 MAP kinase-dependent mechanism. | Lin, CH., et al. 2001. Life Sci. 69: 2503-15. PMID: 11693258
- 3-Morpholinosydnonimine hydrochloride induces p53-dependent apoptosis in murine primary neural cells: a critical role for p21(ras)-MAPK-p19(ARF) pathway. | Kaji, T., et al. 2002. Nitric Oxide. 6: 125-34. PMID: 11890736
- Involvement of p38 mitogen-activated protein kinase in PLL-AGE-induced cyclooxgenase-2 expression. | Lin, CH., et al. 2002. Eur J Pharmacol. 438: 143-52. PMID: 11909605
- Effect of hypoxia and endothelial loss on vascular smooth muscle cell responsiveness to VEGF-A: role of flt-1/VEGF-receptor-1. | Parenti, A., et al. 2002. Cardiovasc Res. 55: 201-12. PMID: 12062723
- Advanced glycosylation end products induce inducible nitric oxide synthase (iNOS) expression via a p38 MAPK-dependent pathway. | Chang, PC., et al. 2004. Kidney Int. 65: 1664-75. PMID: 15086905
- Chloroquine induces the expression of inducible nitric oxide synthase in C6 glioma cells. | Chen, TH., et al. 2005. Pharmacol Res. 51: 329-36. PMID: 15683746
- BCP crystals increase prostacyclin production and upregulate the prostacyclin receptor in OA synovial fibroblasts: potential effects on mPGES1 and MMP-13. | Molloy, ES., et al. 2007. Osteoarthritis Cartilage. 15: 414-20. PMID: 17123841
- The p38 pathway inhibitor SB202190 activates MEK/MAPK to stimulate the growth of leukemia cells. | Hirosawa, M., et al. 2009. Leuk Res. 33: 693-9. PMID: 18995898
- Sodium benzoate, a metabolite of cinnamon and a food additive, reduces microglial and astroglial inflammatory responses. | Brahmachari, S., et al. 2009. J Immunol. 183: 5917-27. PMID: 19812204
- Simvastatin inhibits the activation of p21ras and prevents the loss of dopaminergic neurons in a mouse model of Parkinson's disease. | Ghosh, A., et al. 2009. J Neurosci. 29: 13543-56. PMID: 19864567
- Zoledronic acid inhibits the pentose phosphate pathway through attenuating the Ras-TAp73-G6PD axis in bladder cancer cells. | Wang, X., et al. 2015. Mol Med Rep. 12: 4620-4625. PMID: 26126921
- Lovastatin and phenylacetate inhibit the induction of nitric oxide synthase and cytokines in rat primary astrocytes, microglia, and macrophages. | Pahan, K., et al. 1997. J Clin Invest. 100: 2671-9. PMID: 9389730
- Sphingomyelinase and ceramide stimulate the expression of inducible nitric-oxide synthase in rat primary astrocytes. | Pahan, K., et al. 1998. J Biol Chem. 273: 2591-600. PMID: 9446561
- Protein prenyl transferase activities of Plasmodium falciparum. | Chakrabarti, D., et al. 1998. Mol Biochem Parasitol. 94: 175-84. PMID: 9747968
Inhibitor of:
Farnesyl Transferase.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
FPT Inhibitor II, 1 mg | sc-221626 | 1 mg | $191.00 |