Anticorps FKBP12 (8): sc-135908
- L'anticorps FKBP12 8 est un monoclonal IgG1 de souris fourni en 50 µg/0.5 ml
- dirigé contre les acides aminés 1-108 correspondant à la séquence totale de FKBP12 d'origine human
- recommandé pour la détection de FKBP12 d'origine mouse, rat, human et canine par WB, IP et IF; déconseillé pour IP
- Nous testons actuellement encore nos anticorps secondaires pour trouver la meilleure protéine de liaison pour cet anticorps primaire FKBP12 (8). Veuillez nous contacter si vous avez des questions concernant les réactifs de détection secondaire appropriés.
Immunophilins are a highly conserved family of cis-trans peptidyl-prolyl isomerases which bind to and mediate the effects of immunosuppressive drugs such as Cyclosporin, FK506 and Rapamycin. The prototypic member of the family, FKBP12, was originally identified as a target of FK506 and Rapamycin activity. FKBP12 is an abundant, evolutionarily conserved cytoplasmic protein. Although the molecular role of FKBP12 activity is not well understood, the protein has been implicated as a regulator of diverse array of cellular processes including T cell activation, entry into the cell cycle and intracellular calcium release. Interestingly, FKBP12 has been shown to associate with the intracellular cytoplasmic domain of the type I TGFβ receptor. This association is constitutive and not dependent on the activation of the receptor.
Informations pour la commande
| Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps FKBP12 (8) | sc-135908 | 50 µg/0.5 ml | $316.00 |