Date published: 2025-9-9

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Anticorps FADD (F-12): sc-166516

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Fiches techniques
  • L'Anticorps FADD (F-12) est un monoclonal de souris IgG1 κ, cité dans 3 publications, fourni en 200 µg/ml
  • spécifique d'un épitope situé entre les acides aminés 187-205 au niveau C-terminus de FADD d'origine mouse
  • recommandé pour la détection de FADD d'origine mouse et rat par WB, IP, IF et ELISA
  • Voir FADD (G-4): sc-271748 pour d'autres anticorps conjugués FADD, dont AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 et 790.
  • m-IgG Fc BP-HRP, 1 BP-HRP">m-IgG1 BP-HRP et m-IgGκ BP-HRP sont les réactifs de détection secondaire préférés pour l'anticorps FADD (F-12) pour les applications WB. Ces réactifs sont désormais proposés en lots avec l'anticorps FADD (F-12)(voir les informations de commande ci-dessous).

ACCÈS RAPIDE AUX LIENS

VOIR ÉGALEMENT...

In contrast to growth factors which promote cell proliferation, FAS ligand (FAS-L) and tumor necrosis factor (TNF) rapidly induce apoptosis. Cellular response to FAS-L and TNF is mediated by structurally related receptors containing a conserved "death domain" and belonging to the TNF receptor superfamily. TRADD, FADD and RIP are FAS/TNF-RI interacting proteins that contain a death domain homologous region (DDH). TRADD (TNF-RI-associated death domain) and FADD (FAS-associated death domain) associate with the death domains of both FAS and TNF-RI via their DDH regions. Overexpression of TRADD leads to NFkB activation and apoptosis in the absence of TNF. Overexpression of FADD causes apoptosis, which can be blocked by the cow pox protein CrmA, suggesting that FADD lies upstream of ICE and possibly other serine proteases. The receptor interacting protein, RIP, associates with FAS exclusively via its DDH, and this association is abrogated in lpr mutants. Unlike TRADD and FADD, RIP contains a putative amino terminal kinase domain.

Pour la Recherche Uniquement. Non destiné à un usage diagnostique ou thérapeutique.

Informations pour la commande

Nom du produitRef. CatalogueCOND.Prix HTQTÉFavoris

Anticorps FADD (F-12)

sc-166516
200 µg/ml
$316.00

FADD (F-12): m-IgG Fc BP-HRP Kit

sc-537500
200 µg Ab; 10 µg BP
$354.00

FADD (F-12): m-IgGκ BP-HRP Kit

sc-534782
200 µg Ab; 40 µg BP
$354.00

FADD (F-12): m-IgG1 BP-HRP Kit

sc-545204
200 µg Ab; 20 µg BP
$354.00

FADD (F-12) peptide neutralisant

sc-166516 P
100 µg/0.5 ml
$68.00

What application is the blocking peptide sc-166516 P appropriate for?

Posée par: cjMara
Thank you for your question. The blocking peptide is intended for use as a negative control, by pre-adsorbing the mouse monoclonal antibody against the antigen. For full protocol details, please contact our Technical Services Department or view our online protocol here: https://www.scbt.com/scbt/resources/protocols/peptide-neutralization
Répondue par: Technical Support
Date de publication: 2017-02-27
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Rated 5 de 5 de par Nice Western blot data of FADD expression in nonNice Western blot data of FADD expression in non-transfected and mouse FADD transfected 293T whole cell lysates. -SCBT QC
Date de publication: 2014-06-03
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Anticorps FADD (F-12) est évalué 5.0 de 5 de 1.
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