Molecular structure of Ezetimibe, CAS Number: 163222-33-1
Ezetimibe (CAS 163222-33-1)
See product citations (12)
Alternate Names:
Zetia
Application:
Ezetimibe is a cholesterol transport inhibitor that binds to NPC1L1
CAS Number:
163222-33-1
Purity:
≥99%
Molecular Weight:
409.43
Molecular Formula:
C24H21F2NO3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Ezetimibe has been reported to be a cholesterol transport inhibitor. Mechanistic studies show that this compound directly affects Niemann-Pick C1-like 1 (NPC1L1) and prevents it from incorporating into clathrin-coated vesicles. NPC1L1 is a polytopic transmembrane protein that facilitates absorption of cholesterol via clathrin/AP2-mediated endocytosis. By binding to NPC1L1, ezetimibe prevents endocytosis of this protein therefore blocking cholesterol transfer across membranes.
Ezetimibe (CAS 163222-33-1) References
- Ezetimibe-induced hyperlipidaemia. | Doherty, E., et al. 2005. Int J Clin Pract Suppl. 3-5. PMID: 15875607
- Ezetimibe ameliorates cholecystosteatosis. | Mathur, A., et al. 2007. Surgery. 142: 228-33. PMID: 17689690
- Ezetimibe and simvastatin reduce inflammation, disease activity, and aortic stiffness and improve endothelial function in rheumatoid arthritis. | Mäki-Petäjä, KM., et al. 2007. J Am Coll Cardiol. 50: 852-8. PMID: 17719471
- The cholesterol absorption inhibitor ezetimibe acts by blocking the sterol-induced internalization of NPC1L1. | Ge, L., et al. 2008. Cell Metab. 7: 508-19. PMID: 18522832
- Ezetimibe in diabetes: more than cholesterol lowering? | Sarigianni, M., et al. 2010. Curr Med Res Opin. 26: 2517-20. PMID: 20843163
- Ezetimibe and vascular endothelial function. | Ikeda, S. and Maemura, K. 2011. Curr Vasc Pharmacol. 9: 87-98. PMID: 21044017
- Ezetimibe and low density lipoprotein subfractions: an ongoing debate. | Katsiki, N., et al. 2011. Curr Med Res Opin. 27: 693-5. PMID: 21275848
- Aminolysis of ezetimibe. | Baťová, J., et al. 2015. J Pharm Biomed Anal. 107: 495-500. PMID: 25686539
- Liver Injury Associated With Ezetimibe Monotherapy. | Kanagalingam, T., et al. 2021. CJC Open. 3: 195-197. PMID: 33644733
- Synthesis and Modeling of Ezetimibe Analogues. | Salgado, MM., et al. 2021. Molecules. 26: PMID: 34067439
- Ezetimibe Prevents IL-1β-induced Inflammatory Reaction in Mouse Chondrocytes via Modulating NF-κB and Nrf2/HO-1 Signaling Crosstalk. | Weng, Q., et al. 2022. Curr Pharm Biotechnol. 23: 1772-1780. PMID: 34983342
- Preformulation Studies of Ezetimibe-Simvastatin Solid Dispersions in the Development of Fixed-Dose Combinations. | Górniak, A., et al. 2022. Pharmaceutics. 14: PMID: 35631498
- Ezetimibe ameliorates clinical symptoms in a mouse model of ankylosing spondylitis associated with suppression of Th17 differentiation. | Moon, J., et al. 2022. Front Immunol. 13: 922531. PMID: 36059546
Inhibitor of:
AADACL1, ABCG4, ABCG5, ABHD3, ACSVL3, Afamin, Angptl3, APO, apoA-IV, apoAL, apoB48R, apoE, ApoER2, apoF, APOL (Apolipoprotein L), apoL-VI, apoM, APOP1, ATP-binding cassette sub-family A (ABCA), BACH1, C20orf79, CCDC132, CIDE-B, DDHD2, DSCD75, EBPL, EG666803, Endothelial Lipase, GGPL-I, Gm1679, Hepatic Lipase, LCAT, LDL, LDLRAD2, LDLRAD3, LIMP I, LIP1, lipoprotein, Lmf2, LOC55908, LPAAT-ε, LSR, MENTHO, MGAT2, MYLIP, NTCP, Olfr427, Olr14, Olr1590, Olr192, Olr208, Olr213, Olr255, Olr808, PC-TP, PDZK1, Plb3, PLC ε, SCP2D1, SEC14L2, SEC14L3, SEC14L4, SgK223, SOAT2, Squalene synthetase, STARD, StARD10, TSPAN7, and XKR4.Activator of:
AADACL2, ABCA14, apoC1, ARH, ATP8B, ATP8B3, C20orf79, CH25H, CYP27A1, CYP46, GRAMD1C, LDLR, LDLRAD1, LDLRAD2, LDLRAD4, Lmf1, Lmf2, LOC284274, LOC339674, NPAL2, PC7/8, PLTP, SCP-2, SCP2D1, Sodium Taurochenodeoxycholate, SR-B1, StARD6, TBL2, and TM7SF3.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Ezetimibe, 25 mg | sc-205690 | 25 mg | $96.00 | |||
Ezetimibe, 100 mg | sc-205690A | 100 mg | $241.00 |