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The eosinophil major basic protein (EMBP), also designated MBP, PRG2, proteoglycan 2, BMPG, or bone marrow natural killer cell activator, is a constituent of the crystalline core of the eosinophil granule. High levels of the pro-EMBP are present in placenta and pregnancy serum, where it exists as a complex with several other proteins including pregnancy-associated plasma protein A (PAPPA), angiotensinogen (AGT) and C3dg. EMBP may influence antiparasitic defense mechanisms as a cytotoxin and helminthotoxin, and may play a role in immune hypersensitivity reactions. EMBP stimulates an Src kinase-dependent activation of class I (A) phosphoinositide 3-kinase and, in turn, activation of protein kinase C ζ in neutrophils. EMBP transcription is under regulation by novel combinatorial interactions of GATA-1, PU.1, and C/EBPε isoforms.
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Informations pour la commande
Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps EMBP (F-2) | sc-365702 | 200 µg/ml | $316.00 | |||
EMBP (F-2): m-IgG Fc BP-HRP Kit | sc-537825 | 200 µg Ab; 10 µg BP | $354.00 | |||
EMBP (F-2): m-IgGκ BP-HRP Kit | sc-535240 | 200 µg Ab; 40 µg BP | $354.00 | |||
EMBP (F-2): m-IgG1 BP-HRP Kit | sc-545380 | 200 µg Ab; 20 µg BP | $354.00 |