Anticorps EDG-1/S1P1/S1PR1 (F-6): sc-271423
- L'Anticorps EDG-1/S1P1/S1PR1 (F-6) est un monoclonal de souris IgG1 (chaîne légère kappa) fourni en 200 µg/ml
- spécifique d'un épitope situé entre les acides aminés 302-351 près de C-terminus de EDG-1 d'origine human
- recommandé pour la détection de EDG-1 d'origine human par WB, IP, IF et ELISA
- Voir EDG-1/S1P1/S1PR1 (A-6): sc-48356 pour d'autres anticorps conjugués EDG-1/S1P1/S1PR1, dont AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 et 790.
- m-IgG Fc BP-HRP, 1 BP-HRP">m-IgG1 BP-HRP et m-IgGκ BP-HRP sont les réactifs de détection secondaire préférés pour l'anticorps EDG-1/S1P1/S1PR1 (F-6) pour les applications WB. Ces réactifs sont désormais proposés en lots avec l'anticorps EDG-1/S1P1/S1PR1 (F-6)(voir les informations de commande ci-dessous).
ACCÈS RAPIDE AUX LIENS
VOIR ÉGALEMENT...
The EDG (endothelial differentiation gene) family of G protein coupled receptors consists of eight family members that bind lysophospholipid (LPL) mediators, including sphingosine-1-phosphate (SPP) and lysophosphatidic acid (LPA). EDG-1, EDG-3, EDG-5 (also designated H218 and AGR16) and EDG-8 bind SPP with high affinity. EDG-6 is a low affinity receptor for SPP. LPA preferentially binds to EDG-2, EDG-4 and EDG-7. The EDG receptors couple to multiple G proteins to signal through Ras, MAP kinase, Rho, Phospholipase C or other tyrosine kinases, which lead to cell survival, growth, migration and differentiation. EDG-1 signals through Gi proteins to activate Akt and is expressed in glioma cells. EDG-2 is expressed in brain, especially in white matter tract regions, while EDG-3 is expressed in cardiovascular tissue and in cerebellum. EDG-4 is highly expressed on leukocytes and brain, and EDG-5 has wide tissue distribution, including cardiovascular tissue and brain. EDG-6, which is expressed in lymphoid and hematopoietic tissues and in lung, signals through G(i/o) proteins, which activate growth related pathways.
Informations pour la commande
| Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps EDG-1/S1P1/S1PR1 (F-6) | sc-271423 | 200 µg/ml | $316.00 | |||
EDG-1/S1P1/S1PR1 (F-6): m-IgG Fc BP-HRP Kit | sc-537630 | 200 µg Ab; 10 µg BP | $354.00 | |||
EDG-1/S1P1/S1PR1 (F-6): m-IgGκ BP-HRP Kit | sc-534955 | 200 µg Ab; 40 µg BP | $354.00 | |||
EDG-1/S1P1/S1PR1 (F-6): m-IgG1 BP-HRP Kit | sc-545270 | 200 µg Ab; 20 µg BP | $354.00 | |||
EDG-1/S1P1/S1PR1 (F-6) peptide neutralisant | sc-271423 P | 100 µg/0.5 ml | $68.00 |