DOT1L1 Antibody (E-2): sc-376036
- DOT1L1 Antibody (E-2) is a mouse monoclonal IgG2b κ, cited in 1 publications, provided at 200 µg/ml
- raised against amino acids 1-300 mapping at the N-terminal of DOT1L1 of human origin
- recommended for detection of DOT1L1 of mouse, rat and human origin by WB, IP, IF and ELISA
- TransCruz reagent for ChIP application (sc-376036 X, 200 µg/0.1 ml)
- m-IgG2b BP-HRP is the preferred secondary detection reagent for DOT1L1 Antibody (E-2) for WB applications. This reagent is now offered in a bundle with DOT1L1 Antibody (E-2) (see ordering information below).
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DOT1L1 Antibody (E-2) is a mouse monoclonal IgG2b antibody that detects DOT1L1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). DOT1L1, also known as DOT1L (DOT1-like, histone H3 methyltransferase), is a 1739 amino acid protein that plays a crucial role in regulating gene expression by methylating lysine residues on histones, thereby influencing chromatin structure and function. Unlike most histone methyltransferases that possess a SET domain, DOT1L1 operates through a distinct mechanism, which is significant for its unique role in epigenetic regulation. DOT1L1 is predominantly localized in the nucleus and is highly expressed in tissues such as testis, lung, and kidney, highlighting its importance in cellular processes. Furthermore, DOT1L1 interacts with various MLL-fusion partners associated with acute leukemia, contributing to oncogenesis and making DOT1L1 a critical target for cancer research. The presence of two isoforms of DOT1L1, resulting from alternative splicing, adds another layer of complexity to its function and regulation, underscoring the need for precise tools like anti-DOT1L1 antibody (E-2) for studying its diverse roles in health and disease.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
DOT1L1 Antibody (E-2) | sc-376036 | 200 µg/ml | $322.00 | |||
DOT1L1 Antibody (E-2): m-IgG2b BP-HRP Bundle | sc-548584 | 200 µg Ab; 10 µg BP | $361.00 | |||
DOT1L1 Antibody (E-2) X | sc-376036 X | 200 µg/0.1 ml | $322.00 |