Les Produits Chimiques ChemCruz™
DOT1L1 Inhibiteurs pour l'analyse fonctionnelle des réponses cellulaires de DOT1L1
Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
Please note: We can not ship to PO boxes
ACCÈS RAPIDE AUX LIENS
Express Blue Ice
Express Dry Ice
Animal Health Prescription Item
SHIPPING METHODS & CHARGES
Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
DOT1L1, also known as DOT1L (DOT1-like, histone H3 methyltransferase), DOT1 or KMT4, is a 1739 amino acid homolog of the yeast DOT1 (disruptor of telomeric silencing-1) protein. Localized to the nucleus and highly expressed in testis, lung and kidney, DOT1L1 is a histone methyltransferase that transfers methyl groups from S-adenosyl-L-methionine to lysine residues on various substrates, such as nucleosomes or histones. While most histone methyltransferases contain a SET domain through which they confer their enzymatic activity, DOT1L1 does not contain this characteristic domain and is, therefore, thought to function through a different mechanism. DOT1L1 can bind with several MLL-fusion partners found in acute leukemia and, through this binding, can promote oncogenesis. Two isoforms of DOT1L1 are expressed due to alternative splicing events.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.