DNA-PKCS Antibody (E-6): sc-390698
- DNA-PKCS Antibody (E-6) is a mouse monoclonal IgG2b κ, cited in 18 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 3488-3511 of DNA-PKcs of human origin
- recommended for detection of DNA-PKcs of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- See DNA-PKCS (G-12): sc-390849 for DNA-PKCS antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgGκ BP-HRP is the preferred secondary detection reagent for DNA-PKCS Antibody (E-6) for WB and IHC(P) applications. This reagent is now offered in a bundle with DNA-PKCS Antibody (E-6) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
QUICK LINKS
SEE ALSO...
DNA-PKCS Antibody (E-6) is a mouse monoclonal IgG2b antibody that detects DNA-PKCS in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). DNA-PKCS, a critical component of the DNA-dependent protein kinase complex, plays a vital role in the repair of double-strand breaks (DSBs) in DNA, which is essential for maintaining genomic stability and preventing cancer. DNA-PKCS is primarily located in the nucleus, where DNA-PKCS is involved in the non-homologous end joining (NHEJ) pathway, a key mechanism for repairing DSBs that can arise from environmental factors or during normal cellular processes such as V(D)J recombination. Proper functioning of DNA-PKCS is crucial, as defects in DNA-PKCS can lead to severe consequences, including increased sensitivity to ionizing radiation and a higher risk of developing malignancies. Additionally, DNA-PKCS interacts with other proteins in the NHEJ pathway, such as Ku70/Ku80, to form a complex that recognizes and binds to DSBs, facilitating their repair. anti-DNA-PKCS antibody (E-6) is an invaluable tool for researchers studying DNA repair mechanisms, cancer biology, and the cellular response to DNA damage.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
DNA-PKCS Antibody (E-6) References:
- DNA-PKcs promotes alcohol-related liver disease by activating Drp1-related mitochondrial fission and repressing FUNDC1-required mitophagy. | Zhou, H., et al. 2019. Signal Transduct Target Ther. 4: 56. PMID: 31839999
- DNA-PKcs kinase activity stabilizes the transcription factor Egr1 in activated immune cells. | Waldrip, ZJ., et al. 2021. J Biol Chem. 297: 101209. PMID: 34562454
- DNA-PKcs as an upstream mediator of OCT4-induced MYC activation in small cell lung cancer. | Wei, SJ., et al. 2023. Biochim Biophys Acta Gene Regul Mech. 1866: 194939. PMID: 37116859
- Cryo-EM visualization of DNA-PKcs structural intermediates in NHEJ. | Chen, S., et al. 2023. Sci Adv. 9: eadg2838. PMID: 37256947
- Phosphorylation of DNA-PKcs at the S2056 cluster ensures efficient and productive lymphocyte development in XLF-deficient mice. | Zhu, Y., et al. 2023. Proc Natl Acad Sci U S A. 120: e2221894120. PMID: 37307443
- DNA-PKcs inhibitors sensitize neuroendocrine tumor cells to peptide receptor radionuclide therapy in vitro and in vivo. | Reuvers, TGA., et al. 2023. Theranostics. 13: 3117-3130. PMID: 37351169
- DNA-PKcs regulates myogenesis in an Akt-dependent manner independent of induced DNA damage. | Sutcu, HH., et al. 2023. Cell Death Differ. 30: 1900-1915. PMID: 37400716
- Eicosapentaenoic acid enhances the sensitivity of osteosarcoma to cisplatin by inducing ferroptosis through the DNA-PKcs/AKT/NRF2 pathway and reducing PD-L1 expression to attenuate immune evasion. | Zhang, Y., et al. 2023. Int Immunopharmacol. 125: 111181. PMID: 37951196
- Disruption of DNA-PKcs-mediated cGAS retention on damaged chromatin potentiates DNA damage-inducing agent-induced anti-multiple myeloma activity. | Zhang, JN., et al. 2024. Br J Cancer. 131: 430-443. PMID: 38877108
- The DNA repair protein DNA-PKcs modulates synaptic plasticity via PSD-95 phosphorylation and stability. | Mollinari, C., et al. 2024. EMBO Rep. 25: 3707-3737. PMID: 39085642
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
DNA-PKCS Antibody (E-6) | sc-390698 | 200 µg/ml | $322.00 | |||
DNA-PKCS Antibody (E-6): m-IgGκ BP-HRP Bundle | sc-535639 | 200 µg Ab; 40 µg BP | $361.00 | |||
DNA-PKCS (E-6) Neutralizing Peptide | sc-390698 P | 100 µg/0.5 ml | $69.00 |