DNA-PKCS Antibody (E-3): sc-390495
- DNA-PKCS Antibody (E-3) is a mouse monoclonal IgM κ, cited in 5 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 3493-3511 at the C-terminus of DNA-PKCS of human origin
- recommended for detection of DNA-PKcs of mouse, rat and human origin by WB, IP, IF and ELISA
- See DNA-PKCS (G-12): sc-390849 for DNA-PKCS antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgGκ BP-HRP is the preferred secondary detection reagent for DNA-PKCS Antibody (E-3) for WB applications. This reagent is now offered in a bundle with DNA-PKCS Antibody (E-3) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
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DNA-PKCS Antibody (E-3) is a mouse monoclonal IgM antibody that detects DNA-PKCS in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). DNA-PKCS, a critical component of the DNA-dependent protein kinase complex, plays a vital role in the repair of double-strand breaks (DSBs) in DNA, which is essential for maintaining genomic stability and preventing cancer. DNA-PKCS is primarily located in the nucleus, where DNA-PKCS is involved in the non-homologous end joining (NHEJ) pathway, a key mechanism for repairing DSBs that can arise from various sources, including ionizing radiation and oxidative stress. Proper functioning of DNA-PKCS is crucial, as defects in DNA-PKCS can lead to severe consequences, such as impaired DNA repair, increased sensitivity to radiation, and a higher risk of developing malignancies. Additionally, DNA-PKCS interacts with other proteins involved in the DNA damage response, including Ku proteins, which are essential for the formation of the DNA-PK complex. anti-DNA-PKCS antibody (E-3) is an invaluable tool for researchers studying DNA repair mechanisms, cancer biology, and the cellular response to genotoxic stress.
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DNA-PKCS Antibody (E-3) References:
- DNA-PKcs has KU-dependent function in rRNA processing and haematopoiesis. | Shao, Z., et al. 2020. Nature. 579: 291-296. PMID: 32103174
- DNA-PKcs kinase activity orchestrates both end-processing and end-ligation. | Menolfi, D. and Zha, S. 2022. Trends Cell Biol. 32: 91-93. PMID: 34953661
- Structural insights into inhibitor regulation of the DNA repair protein DNA-PKcs. | Liang, S., et al. 2022. Nature. 601: 643-648. PMID: 34987222
- DNA-PKcs-dependent phosphorylation of RECQL4 promotes NHEJ by stabilizing the NHEJ machinery at DNA double-strand breaks. | Lu, H., et al. 2022. Nucleic Acids Res. 50: 5635-5651. PMID: 35580045
- DNA-PKcs restricts Zika virus spreading and is required for effective antiviral response. | Patricio, DO., et al. 2022. Front Immunol. 13: 1042463. PMID: 36311766
- DNA-dependent protein kinase catalytic subunit (DNA-PKcs) drives chronic kidney disease progression in male mice. | Yang, Y., et al. 2023. Nat Commun. 14: 1334. PMID: 36906617
- DNA-PKcs is required for cGAS/STING-dependent viral DNA sensing in human cells. | Hristova, DB., et al. 2024. iScience. 27: 108760. PMID: 38269102
- DNA-PKcs Phosphorylates Cofilin2 to Induce Endothelial Dysfunction and Microcirculatory Disorder in Endotoxemic Cardiomyopathy. | Du, Y., et al. 2024. Research (Wash D C). 7: 0331. PMID: 38550779
- DNA-PKcs/AKT1 inhibits epithelial-mesenchymal transition during radiation-induced pulmonary fibrosis by inducing ubiquitination and degradation of Twist1. | Yan, Z., et al. 2024. Clin Transl Med. 14: e1690. PMID: 38760896
- The multifaceted functions of DNA-PKcs: implications for the therapy of human diseases. | Wu, J., et al. 2024. MedComm (2020). 5: e613. PMID: 38898995
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
DNA-PKCS Antibody (E-3) | sc-390495 | 200 µg/ml | $322.00 | |||
DNA-PKCS Antibody (E-3): m-IgGκ BP-HRP Bundle | sc-552526 | 200 µg Ab; 40 µg BP | $361.00 | |||
DNA-PKCS (E-3) Neutralizing Peptide | sc-390495 P | 100 µg/0.5 ml | $69.00 |